| 中药糖络宁对链脲佐菌素诱导糖尿病大鼠黏附分子的影响 |
| |
| 引用本文： | 高彦彬,张涛静,周晖,关崧,谢培凤,商学征,易文明,盛彤,张清怡.中药糖络宁对链脲佐菌素诱导糖尿病大鼠黏附分子的影响[J].中华中医药杂志,2009(7). |
| |
| 作者姓名： | 高彦彬 张涛静 周晖 关崧 谢培凤 商学征 易文明 盛彤 张清怡 |
| |
| 作者单位： | 北京中医药大学东方医院; |
| |
| 基金项目： | 教育部高等学校博士点基金资助项目(No.20050026002); 国家自然科学基金资助项目(No.30873253) |
| |
| 摘 要： | 目的:观察中药复方糖络宁对糖尿病大鼠黏附分子的影响。方法:采用链脲佐菌素糖尿病大鼠模型,造模成功后随机分为模型组、西药组及糖络宁组给药,共给药12周,给药结束后,利用流式细胞仪观察糖络宁对糖尿病大鼠黏附分子的影响。结果:与正常组大鼠比较,模型组糖尿病大鼠单个核细胞表面CD54、CD62P的表达明显增强(P<0.01);与模型组大鼠比较,糖络宁组大鼠CD54、CD62P表达显著下降(P<0.01),糖络宁组与西药组比较也有显著性下降(P<0.05)。结论:糖络宁可以有效降低糖尿病大鼠黏附分子CD54、CD62P的表达,这可能是糖络宁治疗糖尿病周围神经病变的机制之一。
|
| 关 键 词： | 糖尿病大鼠 糖络宁 黏附分子 |
Effect of Tangluoning on adhesion molecules in streptozotocin induced diabetic rats |
| |
| GAO Yan-bin,ZHANG Tao-jing,ZHOU Hui,GUAN Song,XIE Pei-feng,SHANG Xue-zheng,YI Wen-ming,SHENG Tong,ZHANG Qing-yi.Effect of Tangluoning on adhesion molecules in streptozotocin induced diabetic rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(7). |
| |
| Authors: | GAO Yan-bin ZHANG Tao-jing ZHOU Hui GUAN Song XIE Pei-feng SHANG Xue-zheng YI Wen-ming SHENG Tong ZHANG Qing-yi |
| |
| Institution: | GAO Yan-bin,ZHANG Tao-jing,ZHOU Hui,GUAN Song,XIE Pei-feng,SHANG Xue-zheng,YI Wen-ming,SHENG Tong,ZHANG Qing-yi(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China) |
| |
| Abstract: | Objective:To investigate the effect of TangLuoNing(TLN) on adhesion molecules in streptozotocin(STZ) induced diabetic rats.Methods:STZ induced diabetic rats were randomized to diabetic model group,methycobal group,TLN group.The levels of CD54,CD62P of the animals were checked after 12 weeks,treatment.Results:Compare with normal rats group,CD54,CD62P activities in all diabetic groups were signifi cant higher(P<0.01).CD54,CD62P activities in TLN group and Methycobal group were lower.But only the activity of T... |
| |
| Keywords: | Diabetic rats Tangluoning Adhesion molecules |
| 本文献已被 CNKI 等数据库收录！ |
|
