| 辐射诱导的适应性效应及其分子机制 |
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| 引用本文： | 袁德晓,潘燕,沈波,邵春林.辐射诱导的适应性效应及其分子机制[J].国际放射医学核医学杂志,2007,31(5):296-299. |
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| 作者姓名： | 袁德晓 潘燕 沈波 邵春林 |
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| 作者单位： | 200032 上海, 复旦大学放射医学研究所第三研究室 |
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| 基金项目： | 国家自然科学基金，教育部跨世纪优秀人才培养计划，上海市浦江人才计划 |
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| 摘 要： | 辐射适应性效应是一种生物防御机制,是指低剂量辐射可以增强细胞对随后高剂量照射的抵抗能力,从而降低高辐射引起的各种损伤.目前为止,RAR的分子机制还不清楚,研究主要涉及DNA损伤修复、细胞周期调控、细胞对抗氧化应激系统以及应激反应蛋白,参与细胞信号传递的分子主要包括蛋白激酶C、有丝分裂原激活蛋白激酶、p53蛋白、共济失调性毛细血管扩张突变基因及DNA依赖性蛋白激酶.
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| 关 键 词： | 辐射效应 低剂量辐射 信号转导 |
| 收稿时间： | 2007-05-24 |
Radioadaptive response and its molecular mechanism |
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| YUAN De-xiao,PAN Yan,SHEN Bo,SHAO Chun-lin.Radioadaptive response and its molecular mechanism[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(5):296-299. |
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| Authors: | YUAN De-xiao PAN Yan SHEN Bo SHAO Chun-lin |
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| Institution: | The Third Department, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
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| Abstract: | Radioadaptive response is a biological defense of which low dose ionizing radiation induces cellular resistance to the genotoxic effects of subsequent challenge irradiation. However, so for molecular mechanism of radioadaptive response remains obscure. Research is mainly involved in activation of the intracellular repair system, cell cycle regulation system, antioxidative stress system and stress-response protein. Signaling factors involved in cell response to radiation include protein kinase C, mitogen-activated protein kinase, p53 tumor suppressor protein, ataxia-telansiectasia mutated, and DNA-dependent protein kinase. |
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