Suppressed alloreactivity and mixed chimerism in rats with accepted cardiac allografts by intrathymic injection of donor bone marrow cells |
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| Authors: | T. Matsuura Masaaki Imanishi Yasushi Hara Tsukasa Nishioka Seiji Kunikata Takahiro Akiyama Takashi Kurita |
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| Affiliation: | (1) Department of Urology, Osaka Teishin Hospital, 2-6-40 Karasugatsuji, Tennoji, Osaka 543, Japan Fax: +81 67 72 23 02, JP;(2) Department of Urology, Kinki University School of Medicine, Osaka, Japan, JP |
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| Abstract: | Intrathymic injection of donor bone marrow cells (ITBMCs) at the time of transplantation and treatment with antilymphocyte serum (ALS) permitted the indefinite survival of Brown Norway (BN, RT1n) rat heart grafts in 6 out of 8 Lewis (LEW, RT1l) rat recipients. LEW recipients with long-surviving BN heart grafts (LSGs) also accepted additional BN heart grafts without further immunosuppression, though they rejected Piebald Virol Glaxo (PVG, RT1c) rat heart grafts in the usual fashion. In the in vitro study, the proliferative response of the lymphocytes from LEW recipients with LSGs remained suppressed when they were stimulated by BN spleen cells, but not when stimulated by PVG cells. Bone marrow cells (BMCs) from LEW rats with LSGs showed strong, nonspecific, suppressive effects on the proliferative response in the mixed lymphocyte culture reaction, suggesting that one of the possible explanations for tolerance might be the involvement of a suppressor mechanism. Received: 7 August 1996 Received after revision: 12 February 1997 Accepted: 17 February 1997 |
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| Keywords: | Bone marrow cells mixed chimerism rats Chimerism rats intrathymic bone marrow cells Intrathymic donor bone marrow Cardiac transplantation rat bone marrow |
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