| 缬沙坦/氢氯噻嗪复方制剂和缬沙坦降压疗效的比较 |
| |
| 引用本文： | 曹东平,吕军娥,刘永欣,姚文静,容春莉,于薇.缬沙坦/氢氯噻嗪复方制剂和缬沙坦降压疗效的比较[J].中国临床药理学与治疗学,2008,13(10). |
| |
| 作者姓名： | 曹东平 吕军娥 刘永欣 姚文静 容春莉 于薇 |
| |
| 作者单位： | 河北省人民医院心脏中心,石家庄,050051,河北 |
| |
| 摘 要： | 目的:对比缬沙坦/氢氯噻嗪(缬沙坦80mg/氢氯噻嗪12.5mg)复方制剂与缬沙坦(缬沙坦80mg)治疗轻、中度原发性高血压的谷峰比值(TPR)和平滑指数(SI),评价缬沙坦/氢氯噻嗪的降压疗效。方法:选择轻、中度原发性高血压病患者SBP≥140mmHg且<160mmHg(1mmHg=0.133kPa),DBP≥95mmHg并且<110mmHg]84例,随机分为缬沙坦/氢氯噻嗪和缬沙坦组,共服药8周,观察服药前后血压及生化指标的变化。结果:治疗8周后,缬沙坦/氢氯噻嗪组和缬沙坦组降压有效率分别为84.2、52.5,达标率分别为73.9、42.9,两组间差异有统计学意义(P<0.001)。缬沙坦/氢氯噻嗪组TPR为SBP76.7、DBP71.2,均>50;SI为SBP1.14±0.39、DBP1.09±0.27,均>1。缬沙坦组的TPR为SBP77.6、DBP71.3,均>50;SI为SBP1.24±0.39、DBP1.19±0.27,均>1。两组的TPR和SI差别无统计学意义(P>0.05)。结论:缬沙坦80mg/氢氯噻嗪12.5mg复方制剂治疗轻中度原发性高血压患者疗效优于单用缬沙坦80mg,TPR和SI...
|
| 关 键 词： | 缬沙坦/氢氯噻嗪 缬沙坦 原发性高血压 平滑指数 谷峰比值 |
Comparison of valsartan/hydrochlorothiazide and valsartan in the treatment of hypertension |
| |
| CAO Dong-ping,LV Jun-e,LIU Yong-xin,YAO Wen-jing,RONG Chun-li,YU Wei.Comparison of valsartan/hydrochlorothiazide and valsartan in the treatment of hypertension[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(10). |
| |
| Authors: | CAO Dong-ping LV Jun-e LIU Yong-xin YAO Wen-jing RONG Chun-li YU Wei |
| |
| Institution: | CAO Dong-ping; LV Jun-e; LIU Yong-xin; YAO Wen-jing; RONG Chun-li; YU Wei Heart Center of the People s Hospital of Hebei Province; Shijiazhuang 050051; Hebei; China; |
| |
| Abstract: | AIM:To compare the T/P ratio and the smoothness index of blood pressure in the treatment of mild to moderate essential hypertension with fixed-dose valsartan/hydrochlorothiazide(80/12.5 mg) and valsartan(80 mg),and to evaluate the depressurization therapeutic effect of valsartan/hydrochlorothiazide(80/12.5 mg).METHODS:84 patients with mild to moderate essential hypertension(SBP≥140 mm Hg and<160 mm Hg,DBP≥95 mm Hg and<110 mm Hg) had been divided into randomly valsartan/hydrochlorothiazide group and va... |
| |
| Keywords: | valsartan/hydrochlorothiazide valsartan essential hypertension smoothness index T/P ratio |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
