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氯丙嗪抑制大鼠一足福尔马林致炎迟反应痛
引用本文:利梅 李菁锦. 氯丙嗪抑制大鼠一足福尔马林致炎迟反应痛[J]. 中国疼痛医学杂志, 2000, 6(4): 225-228
作者姓名:利梅 李菁锦
作者单位:首都医科大学神经生物学系,北京,100054
基金项目:北京市自然科学基金(7962009)资助项目
摘    要:目的:用福尔马林致炎模型研究蛋白激酶C(PKC)非特异性抑制剂氯丙嗪 在组织损伤所致痛觉过敏中的作用。方法和结果:福尔马林足底皮下注射使大鼠产生疼痛的早反应和迟反应(痛觉过敏),氯丙嗪显著减轻迟反应。提示蛋白激酶C在疼痛信息的传导和中枢敏感化中起重要作用。

关 键 词:福尔马林 氯丙嗪 大鼠 炎症 迟反应疼痛

CHLORPROMAZINE INHIBITS LATE RESPONSES OF PAIN IN RATS WITH ONE PAW INFLAMED BY FORMALIN
LI Mei,LI Qing Jin,LU Guo Wei. CHLORPROMAZINE INHIBITS LATE RESPONSES OF PAIN IN RATS WITH ONE PAW INFLAMED BY FORMALIN[J]. Chinese Journal of Pain Medicine, 2000, 6(4): 225-228
Authors:LI Mei  LI Qing Jin  LU Guo Wei
Affiliation:LI Mei,LI Qing Jin,LU Guo Wei Department of neurobiology,Capital University of Medical Sciences,Beijing
Abstract:Aim:Formalin test was used to examine the role of Chlorpromazine in hyperalgesia induced by tissue injury. Methods and Results: An early and a late response (hyperalgesia) of pain are produced by subcutaneous injection of formalin in one paw of rats. The late response is significantly reduced by a PKC inhibitor, Chlorpromazine. It is suggested that PKC might play an important role in pain process and its central sensitization.
Keywords:Formalin  Pain  Chlorpromazine  R
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