The effect of intracerebroventricularly administered dibutyryl adenosine 3',5'-cyclic monophosphate on cerebrospinal fluid and serum dopamine-beta-hydroxylase in rabbits |
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Authors: | N H Fraeyman W P De Potter P Singh A F De Schaepdryver |
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Affiliation: | Heymans Institute of Pharmacology, University of Ghent Medical School, De Pintelaan 135, B-9000 Ghent, Belgium |
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Abstract: | Intracerebrospinal injected or infused dibutyryl adenosine 3′,5′-cyclic monophosphate provoked (a) an initial small decrease of cerebrospinal fluid dopamine-β-hydroxylase activity which lasted for 2 hours, followed by a significant rise of a 4–6 hours duration, together with a rise in total cerebrospinal fluid protein concentration, (b) a significant increase in serum dopamine-β-hydroxylase activity. Pretreatment of rabbits with two intracisternal injections of 6-hydroxydopamine completely abolished the dibutyryl adenosine 3′,5′-cyclic monophosphate induced release of dopamine-β-hydroxylase in the cerebrospinal fluid but only partially the release of dopamine-β-hydroxylase in the serum. |
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Keywords: | cAMP: adenosine 3′,5′-cyclic monophosphate dBcAMP: dibutyryl adenosine 3′,5′-cyclic monophosphate CSF: cerebrospinal fluid DßH: dopamine-β-hydroxylase CNS: central nervous system 6-OHDA: 6-hydroxydopamine |
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