| 涟波振荡与大鼠颞叶癫癎发作关系的研究 |
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| 引用本文： | 刘献增,刘扬,王微微,高旭光,董婕,陈朝阳,李儒明.涟波振荡与大鼠颞叶癫癎发作关系的研究[J].中华老年心脑血管病杂志,2007,9(8):556-558. |
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| 作者姓名： | 刘献增 刘扬 王微微 高旭光 董婕 陈朝阳 李儒明 |
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| 作者单位： | 1. 100044,北京,北京大学人民医院神经内科
2. 清华大学航空航天系 |
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| 摘 要： | 目的探讨脑电中的涟波振荡与大鼠颞叶癫癎发作的关系。方法10只SD大鼠,在双侧齿状回和海马分别置入深部电极,用氯化锂-毛果芸香碱腹腔注射诱发大鼠颞叶癫癎,记录癫癎发作前后的深部脑电(采样频率10KHz,低通为5000Hz)。用小波变换提取脑电中的涟波和快速涟波成分,并用能量法对癫癎发作前后的涟波成分进行分析。结果涟波和快速涟波的能量变化与癫癎发作的状态十分符合。癫癎发作时,快速涟波和涟波的能量都有明显增加,累积速率大。给予地西泮后,两者的能量都有所减小,累积速率趋于稳定,但快速涟波的能量累积速度降低得更快。结论脑电中的涟波振荡成分对癫癎发作有指示性作用。
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| 关 键 词： | 癫痫 颞叶 脑图 海马 地西泮 电极 植入 |
| 文章编号： | 1009-0126（2007）08-0556-03 |
| 修稿时间： | 2007-01-12 |
Study on relation between ripple oscillations and temporal lobe seizures of rats |
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| LIU Xian zeng, LIU Yang,WANG Wei-wei, et al.Study on relation between ripple oscillations and temporal lobe seizures of rats[J].Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases,2007,9(8):556-558. |
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| Authors: | LIU Xian zeng LIU Yang WANG Wei-wei |
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| Abstract: | Objective To investigate the relation between ripple oscillations of brain wave and temporal lobe seizures of rats. Method Deep electrodes were embedded into bilateral dentate gyri and hippocampus. Deep brain waves before and after seizures of rats with pilocarpine-induced temporal lobe epilepsy were recorded by electroencephalograph. Ripple oscillations were extracted from background brain waves by wavelet transformation.Energy method was used for analyzing between pre-seizure and post-seizure ripple oscillations.Result Visible changes of energy between pre-seizure and post-seizure ripples were found.Conclusion Ripple oscillation of brain wave had indicative effect on seizures. |
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| Keywords: | epilepsy temporal lobe brain mapping hippocampus diazepam electrodes implanted |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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