| P16、E-CD联合表达与乳腺癌侵袭转移关系的研究 |
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| 引用本文： | 宫向前,寿楠海,张永生,邹晓. P16、E-CD联合表达与乳腺癌侵袭转移关系的研究[J]. 山东医药, 2002, 42(3): 1-3 |
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| 作者姓名： | 宫向前 寿楠海 张永生 邹晓 |
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| 作者单位： | 1. 山东大学齐鲁医院,山东济南，250012
2. 青岛大学医学院第二附属医院 |
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| 摘 要： | 为研究 P1 6 、E- c1adherin(E- CD)基因在乳腺癌中的联合表达及临床意义 ,应用免疫组织化学方法(SABC法 )检测了 92例乳腺癌患者癌组织 P1 6、E- CD基因蛋白的表达 ,探讨其与乳腺癌腋淋巴结和远处转移的关系。结果显示 P1 6 、E- CD基因表达与腋淋巴结转移及远隔转移有关 ;提示 P1 6 、E- CD联合基因表达在乳腺癌病程中起重要作用 ;检测其表达情况 ,对筛选乳腺癌术后高危转移患者、加强诊治有临床意义
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| 关 键 词： | 乳腺癌 P16基因 E-cadherin基因 免疫组化 |
| 修稿时间： | 2001-12-06 |
Expression of P16 and E-cadherin in breast carcinoma |
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| Gong Xiangqian,Shou Nanhai,Zhang Yongsheng,et al. Expression of P16 and E-cadherin in breast carcinoma[J]. Shandong Medical Journal, 2002, 42(3): 1-3 |
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| Authors: | Gong Xiangqian Shou Nanhai Zhang Yongsheng et al |
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| Abstract: | To study the clinical significance of P 16 and E cadherin joint expression in breast carcinoma The expression of P 16 and E cadherin gene was studied in human breast carcinomas by immunohistochemistry(SA BC) The relationship between the expression of P 16 and E cadherin to lymph node invasion and metastasis was found The findings suggest that the patients with negative P 16 and E cadherin expression may be associated with metastasis in poor prognosis |
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| Keywords: | Breast carcinoma P 16 gene E cadherin gene Immunohistochemistry |
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