| An Experimental Study on the Treatment with High Dose Dexamethasone of Craniocerebral Injury Caused by 7.62mm Bullets in Dogs |
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| 引用本文： | 朱诚,雷鹏,张光霁,刘荫秋. An Experimental Study on the Treatment with High Dose Dexamethasone of Craniocerebral Injury Caused by 7.62mm Bullets in Dogs[J]. 中国人民解放军军医大学学报, 1989, 0(2) |
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| 作者姓名： | 朱诚 雷鹏 张光霁 刘荫秋 |
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| 作者单位： | Department of Neurosurgery Changzheng Hospital，Second Military Medical University，Shanghai，Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai，Department of Neurosurgery，Changzheng Hospital，Second Military Medical University，Shanghai，Research Institute of Surgery，Third Military Medical College，Chongqing |
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| 摘 要： | The effect of high dose dexamethasone(5 mg/kg wt,intravenous injection)to preventand treat secondary pathological damage due to craniocerebral injury was studied in an animal modelof craniocerebral injury caused by high-velocity missiles in dogs.We observed the physiologicalchanges,analyzed the level of serum and cerebrospinal fluid lactate dehydrogenase,cstimated thepermeability of blood brain barrier(BBB)and studied brain pathology by light and electronmicroscopy.The rusults suggest that high dose dexarnethasone can help to restore the structure andfunction of BBB,protect the brain cells,lessen the secondary pathological damage in the respiratoryand circulatory systams,and reduce the production of lipoperoxides(LPO).
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An Experimental Study on the Treatment with High Dose Dexamethasone of Craniocerebral Injury Caused by 7.62mm Bullets in Dogs |
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| Zhu Cheng Lei Peng Zhang Guangji. An Experimental Study on the Treatment with High Dose Dexamethasone of Craniocerebral Injury Caused by 7.62mm Bullets in Dogs[J]. Journal of Medical Colleges of PLA(China), 1989, 0(2) |
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| Authors: | Zhu Cheng Lei Peng Zhang Guangji |
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| Affiliation: | Zhu Cheng Lei Peng Zhang Guangji Department of Neurosurgery,Changzheng Hospital,Second Military Medical University,ShanghaiLiu Yingqiu Research Institute of Surgery,Third Military Medical College,Chongqing |
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| Abstract: | The effect of high dose dexamethasone(5 mg/kg wt,intravenous injection)to prevent and treat secondary pathological damage due to craniocerebral injury was studied in an animal model of craniocerebral injury caused by high-velocity missiles in dogs.We observed the physiological changes,analyzed the level of serum and cerebrospinal fluid lactate dehydrogenase,cstimated the permeability of blood brain barrier(BBB)and studied brain pathology by light and electron microscopy.The rusults suggest that high dose dexarnethasone can help to restore the structure and function of BBB,protect the brain cells,lessen the secondary pathological damage in the respiratory and circulatory systams,and reduce the production of lipoperoxides(LPO). |
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| Keywords: | head injury gunshot wound experimental model dexamethasone pathology of brain brain blood barrier |
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