益气补肾活血中药治疗小儿哮喘及对血中内皮素和一氧化氮的影响

目的：观察益气补肾活血中药对哮喘患儿血中内皮素－1（ET－1）、一氧化氮（NO）、循环内皮素细胞（CEC）含量的影响，探讨其对小儿哮喘的治疗作用。方法：200例哮喘患儿随机分为常规治疗组和加用中药组，分别在急性期、缓解期进行检测ET－1、NO、CEC，1年后两组各随访20例，观察哮喘的发作次数及ET－1、NO、CEC变化。结果：小儿哮喘急性期ET－1、NO、CEC明显增高。加用中药组血清ET－1、NO、CEC水平较常规治疗组显著下降（P＜0．01），发作次数明显减少。结论：益气补肾活血中药可降低小儿哮喘ET－1、NO、CEC水平，减少小儿哮喘的发作次数，从而提高小儿哮喘的治愈率。

Effect of Yiqi Bushen Huoxue Herbs in Treating Children Asthma and on Levels of Nitric Oxide, Endothelin-1 and Serum Endothelial Cells

Objective: To observe the therapeutic effect of Yiqi Bushen Huoxue herbs (YQBSHX, the Chinese herbs for supplementing Qi, replenishing Kidney and activating blood circulation) on children asthma in regard to its effect on the serum levels of nitric oxide (NO), endothelin 1 (ET 1) and circulating endothelial cells (CEC). Methods: Two hundred children with asthma were divided into two groups, the YQBSHX and the control group, and their serum levels of NO, ET 1 and CEC were detected in acute and remission stage respectively. Twenty cases in each group were followed up for 1 year to observe the frequency of asthma attack and the changes in ET 1, NO and CEC levels. Results: Serum levels of ET 1, NO and CEC in patients of acute stage were obviously raised. After treatment, the above mentioned criteria in the YQBSHX group were significantly lower than those in the control group (P<0 01). And the frequency of attack in the YQBSHX group was markedly reduced. Conclusion: YQBSHX herbs could reduce ET 1, NO and CEC levels in children asthma, lessen the frequency of attack, therefore, to elevate the cure rate of children asthma.