非那甾胺对良性前列腺增生继发血尿的防治作用

目的：探讨5-α还原酶抑制剂非那甾胺对良性前列腺增生患者继发血尿的防治作用。方法：良性前列腺增生继发间歇性血尿患者61例，平均年龄76岁。随机分为非那甾胺治疗组(28例)和对照组(33例)，每周尿常规检查观察血尿复发情况及程度。结果：经过12个月的分组观察，对照组31例中出现反复间歇性血尿20例(64％)，3例因血块堵塞需入院进一步处理，2例因反复血尿行耻骨上前列腺切除术；非那甾胺组28例中出现中、轻度间歇性血尿7例(25％)，无需外科治疗。结论：非那甾胺对良性前列腺增生继发性出血有预防及治疗作用。

A study on the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride

Objective To study the effect of finasteride on hematuria associated with benign prostate hyperplasia. Methods We evaluated 61 patients with intermittent hematuria who were randomized to a finasteride treated group or control group.Routine urinoscopy was carried out once a week in all the 61 patients. Results In the untreated control group hematuria recurred in 20/31 within a year but in only 7/28 in the finasteride group,which was a statistically significant difference (P<0.05).Surgery was required for bleeding only in 5 controls. Conclusions Hematuria secondary benign prostatic hyperplasia may be significant if not treated.Finasteride appears to be effective in eliminating hematuria caused by benign prostate hyperplasia.