真菌性角膜炎的诊治进展

真菌性角膜炎作为常见眼科疾病,其病因和发病机制比较明确,但是该病治疗棘手、预后差.迅速及时诊断和治疗真菌性角膜溃疡是提高临床治愈率,改善预后的关键.本文分析了近年来有关真菌性角膜炎的菌谱变化、归纳了实验室和临床诊断方法如改良的染色方法、共焦显微镜、聚合酶链式反应及分子序列分析技术等,对近来出现的新型抗真菌药物的实验室研究和临床应用进行了详细叙述,并提出选择合适的手术方式以达到最佳的治疗效果.

Update of fungal keratitis diagnosis and treatment

The fungal keratitis is a common ocular disease, and its etiological factor and pathogenesis are definite, but the treatment is difficult and prognosis is poor. It is vital for fungal keratitis to be diagnosed rapidly and treated effectively. This paper had summarized the germ spectrum changes of fungal keratitis, new means of diagnosis adopted both in laboratory and clinical practices, such as improved staining method, confocal biomicroscope, technique of PCR and molecular sequence. There were some details of various new anti-fungal drugs and the available alternatives of surgical treatment for best treating effects.