Effect of various antibiotics on neuromuscular transmission |
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| Authors: | K L Dretchen S D Gergis M D Sokoll J P Long |
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| Affiliation: | Departments of Pharmacology and Anesthesiology, School of Medicine, University of Iowa, Iowa City, Iowa 52240, U.S.A. |
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| Abstract: | The effects of streptomycin, neomycin, kanamycin, polymixin and gentamycin on release of acetylcholine from nerve terminal and on muscle twitch were studied using the frog sciatic nerve-gastrocnemius muscle preparation. The first 4 agents were found to be devoid of any inhibitory action on prejunctional acetylcholine release while producing myoneural blockade. Gentamycin reduced acetylcholine output concomitant with myoneural blockade. It is concluded that the first 4 antibiotics act postsynaptically while gentamycin has a presynaptic component of action. |
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| Keywords: | Neuromuscular blockade Antibiotics Acetylcholine release |
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