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| 丙泊酚对大鼠空间学习记忆能力影响的实验研究 | |
| 引用本文： | 尚游,吴艳,姚尚龙,赵丽,孙雪华,曾因明. 丙泊酚对大鼠空间学习记忆能力影响的实验研究[J]. 中国药理学通报, 2007, 23(6): 764-768 |
| 作者姓名： | 尚游 吴艳 姚尚龙 赵丽 孙雪华 曾因明 |
| 作者单位： | 1. 华中科技大学同济医学院协和医院,麻醉科,湖北,武汉,430022 2. 华中科技大学同济医学院协和医院,神经内科,湖北,武汉,430022 3. 华中科技大学同济医学院,神经生物学系,湖北,武汉,430030 4. 徐州医学院江苏省麻醉学重点实验室,江苏,徐州,221002 |
| 摘 要： | 目的研究丙泊酚对于大鼠空间学习记忆能力的影响。方法给予大鼠丙泊酚(10、30和75mg·kg-1)腹腔注射,给予脂肪乳腹腔注射作为对照,然后应用Morris水迷宫评价其对于大鼠空间学习记忆的影响。结果30和75mg·kg-1的丙泊酚腹腔注射可以损害大鼠的空间学习记忆能力,而10mg·kg-1的丙泊酚腹腔注射不影响大鼠的空间学习记忆能力。结论多次给大鼠腹腔注射丙泊酚重复实施麻醉或镇静可以损害其空间学习记忆能力。 |
| 关 键 词： | 丙泊酚 Morris水迷宫 空间学习记忆 |
| 文章编号： | 1001-1978（2007）06-0764-05 |
| 修稿时间： | 2007-01-24 |
Experimental research on the effect of Propofol on spatial learning and memory in rats |
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| SHANG You,WU Yan,YAO Shang-long,ZHAO Li,SUN Xue-hua,ZENG Yin-ming. Experimental research on the effect of Propofol on spatial learning and memory in rats[J]. Chinese Pharmacological Bulletin, 2007, 23(6): 764-768 | |
| Authors: | SHANG You WU Yan YAO Shang-long ZHAO Li SUN Xue-hua ZENG Yin-ming |
| Affiliation: | 1. Dept of Anestheslology,2 Dept of Neurology, Union Hospital,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China ;3. Dept of Neurobiology, Tonal Medical College ,Huazhong University of Science andTechnology, Wuhan 430030, China; 4. Xuzhou Medical College, Key Laboratory of Anesthesiology of JiangsuProvince, Xuzhou Jiangsu 221002, China |
| Abstract: | Aim To investigate the effect of propofol on the spatial learning and memory in rats. Methods An intraperitoneal (ip) injection of several doses (10, 30, 75 mg·kg-1) of propofol was performed. Intralipid was given (ip) as control. Then, rats were subjected to Morris water maze to evaluate the spatial learning and learning. Results Spatial learning and memory was impaired by repeated 30 and 75 mg·kg-1 Propofol (ip). However, 10 mg·kg-1 propofol had no effect on the spatial learning and memory. Conclusion Multiple repeated anesthesia or sedation by propofol induces the impairment of spatial learning and memory in rats. |
| Keywords: | propofol morris water maze spatial learning and memory |
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