| 老山云芝多糖P对巨噬细胞代谢乙酰低密度脂蛋白的影响 |
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| 引用本文： | 宋武,蔡海江.老山云芝多糖P对巨噬细胞代谢乙酰低密度脂蛋白的影响[J].中国药理学通报,1988(4). |
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| 作者姓名： | 宋武 蔡海江 |
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| 作者单位： | 中国药科大学药理教研室 南京
(宋武)，南京医学院病理生理教研室 南京(蔡海江) |
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| 摘 要： | 老山云芝多糖P可使小鼠腹腔巨噬细胞乙酰LDL(acLDL)受体数目增加。提高巨噬细胞对acLDL的结合、内移和降解。其对巨噬细胞降解acLDL的影响呈浓度效应关系,该效应在云芝多糖100μg/ml时最大,可使巨噬细胞对(~(125)Ⅰ)ac LDL的降解增加77%。实验结果提示,老山云芝多糖P可能通过刺激清道夫受体途径在整体发挥降脂、抗动脉粥样硬化的作用。
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| 关 键 词： | 老山云芝多糖P 巨噬细胞 清道夫受体 胆固醇 乙酰低密度脂蛋白 |
EFFECTS OF LAO SHAN POLYSACCHARIDE P ON THE METABOLISM OF ACETYLATED LDL BY MACROPHAGES |
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| Song Wu.EFFECTS OF LAO SHAN POLYSACCHARIDE P ON THE METABOLISM OF ACETYLATED LDL BY MACROPHAGES[J].Chinese Pharmacological Bulletin,1988(4). |
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| Authors: | Song Wu |
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| Abstract: | It was found that the Lao Shan polsaccharide P, one of the chemical components of polystictus versicolor increased the number of acetylated low density lipoprotein ( acLDL ) receptorsin the macrophages and stimulated the binding, internalization and degradation of (125I ) acLDL by the macrophages in vitro. The effect on cell degradation of ( 125I ) acLDL was dose-effect. At 100μg/ ml of the Lao Shan polysaccharide P, the effect was maximum and the degradation of ( 125I ) acLDL increased 77% ( P<0.001 ) . These results suggested that the Lao Shan polysaccharide P might act as lipid-lowering and antiatherogenic drug in vivo through stimulating the scavenger receptor Pathway of macrophages. |
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| Keywords: | Lao Shan polysaccharide P Macrophage Scavenger receptor Cholesterol Acetyated low density lipoprotein |
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