老年脑梗死患者牛津郡社区脑卒中项目分型与危险因素的关系

目的探讨老年脑梗死患者牛津郡社区脑卒中项目(Oxfordshire community stroke project,OCSP)分型与危险因素的关系。方法将来源于南京脑卒中注册项目的478例患者分为完全前循环梗死组(TACI组,79例)、部分前循环梗死组(PACI组,125例)、后循环梗死组(POCI组,111例)和腔隙性脑梗死组(LACI组,163例),分析各危险因素在OCSP亚型中的分布。结果在4组患者中,高血压、高TC血症、吸烟、饮酒、颈动脉狭窄和短暂性脑缺血发作的发生率差异无显著性意义(P>0.05);TACI组发生心房颤动的比例高于LACI组和POCI组(P<0.01),并高于PACI组(P<0.05);LACI组的糖尿病发生率高于其他3组(P<0.05)。高血压合并糖尿病、高血压合并心房颤动、糖尿病合并心房颤动的患者在OCSP亚型间差异无显著性意义(P>0.05)。结论心房颤动与前循环梗死密切相关,糖尿病更多见于LACI。

Relationship between risk factor profiles and OCSP subtypes in elderly cerebral infarction patients

Objective To investigate the relationship between risk factor profiles and Oxfordshire Community Stroke Project(OCSP) subtypes in elderly cerebral infarction patients.Methods Four hundred and seventy-eight consecutive patients consistent with research scheme were extracted from the Nanjing Stroke Registry Program.The patients were classified as total anterior circulation infarction(TACI),partial anterior circulation infarction(PACI),posterior circulation infarction(POCI) and lacunar infarction(LACI).The risk factors for ischemic stroke in all patients were assessed.Results There was no significant difference in hypertension,hypercholesterolemia,smoking,alcohol consumption,carotid arterial stenosis and history of transient ischemic attack among the 4 OCSP subtypes(P>0.05).Compared with LACI and POCI subtypes,prevalence of atrial fibrillation in patients with TACI subtype was higher(P<0.01).There was significant difference in atrial fibrillation between PACI and TACI subtypes(P<0.05).Diabetes mellitus was more frequent in LACI subgroup than in three other groups(P<0.05).There was no significant difference in prevalence of patients with hypertension and diabetes mellitus,that of patients with hypertension and atrial fibrillation and that of patients with diabetes mellitus and atrial fibrillation among the 4 OCSP subtypes(P>0.05).Conclusions Atrial fibrillation is associated with anterior circulation infarction and diabetes mellitus is associated with LACI.