122例医院败血症病例对照危险因素研究

目的研究医院败血症的危险因素。方法采用回顾性病例对照研究的方法，用SPSS软件，作单因素和Logisitic回归分析，筛选可能的危险因素。结果有14个因素在单因素分析中差异有统计意义，进一步对这14项因素进行Logisitic回归分析表明：基础疾病(0R=5．3)、肿瘤化疗(0R=15．9)、白蛋白＜30g／L(OR=5．9)、血管导管留置＞2天(OR=5．2)、手术时间＞4小时(0R=4．9)、连续使用抗生素(OR=1．1)、同时使用2种以上抗生素(OR=9．0)为医院败血症发生的独立危险因素。结论医院败血症发生是多项因素共同作用的结果。对已筛选的可能的危险因素，需通过前瞻性研究和临床试验进一步证实。

A control study of the risk factors of 122 cases of septicemia

Objective To explore the risk factors of septicemia in hospitals. Methods A retrospective control study of cases was conducted, using SPSS software to conduct single factor and Logistic regression analysis so as toscreen possible risk ractors. Results Differences of 14 factors were shown to be statistically significant in the analysisof single factors. Further Logistic regression analysis of the 14 factors indicate that the following are independent riskfactors of septicemia in hospitals: basic diseases(OR=5.3), tumor chemotherapy(OR=15.9), albumin <30g/L(OR = 5.9), vascular catheterization > 2 days(OR = 5.2), operation time > 4 hours(OR = 4.9), continuous use ofantibiotics(OR = 1.1), and simultaneous of more than 2 Kinds of antibiotics(OR = 9.0). Conclusion Septicemia in hospiatals results from the synergistic effect of a variety of factors. The possible risk factors that have benscreened need to be further confirmed through perspective studies and clinical trials.