Minimal residual disease prior to stem cell transplant for childhood acute lymphoblastic leukaemia |
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Authors: | Goulden Nick Bader Peter Van Der Velden Vincent Moppett John Schilham Marco Masden Hans O Krejci Ondrej Kreyenberg Hermann Lankester Arjan Révész Tom Klingebiel Thomas Van Dongen Jacques |
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Affiliation: | Royal Bristol Hospital for Sick Children, Bristol, UK, Universit?tsKinderklinik, Tübingen, Germany. nick.goulden@ubht.swest.nhs.uk |
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Abstract: | Allogeneic stem cell transplantation (SCT) is a highly effective therapy for childhood acute lymphoblastic leukaemia (ALL). Concerns about unnecessary toxicity and expense mean that SCT is currently largely reserved for children who cannot be cured with chemotherapy. Not surprisingly, many such children also fail SCT. Retrospective studies have shown that a single analysis of minimal residual disease (MRD) pre-SCT identified those at highest risk of relapse. It is now appropriate to call for the universal incorporation of standardized MRD testing into SCT protocols as the next step to maximize the clinical impact of this technology in ALL. |
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Keywords: | MRD BMT childhood ALL relapse Ig/TCR gene rearrangement PCR |
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