| 蝇蛆壳聚糖对高脂血症大鼠的降脂保肝作用 |
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| 引用本文： | 覃容贵,吴建伟,国果,付萍.蝇蛆壳聚糖对高脂血症大鼠的降脂保肝作用[J].中国老年学杂志,2010,30(7). |
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| 作者姓名： | 覃容贵 吴建伟 国果 付萍 |
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| 作者单位： | 1. 贵阳医学院药学院药用植物学与生药学教研室,贵州,贵阳,550004
2. 贵阳医学院基础医学院寄生虫学教研室 |
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| 基金项目： | 贵州省重点技术创新项目资金 |
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| 摘 要： | 目的 研究不同脱乙酰度的蝇蛆壳聚糖对实验性高脂血症大鼠的降脂保肝作用.方法 采用酸碱化学法制备不同脱乙酰度的蝇蛆壳聚糖,并用红外扫描鉴定其结构.取大鼠给高脂饲料造模的同时连续分别给予不同脱乙酰度的蝇蛆壳聚糖8 w,测定大鼠血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量,测定肝脏指数和肝组织中TC含量,并对各组大鼠肝脏进行病理观察.结果 各脱乙酰度组蝇蛆壳聚糖均能显著降低血清TC、TG、LDL-C含量(P<0.01),显著升高HDL-C含量(P<0.01),降低大鼠的肝脏系数及肝组织TC含量(P<0.01),并能减轻肝细胞脂变程度.结论 不同脱乙酰度的蝇蛆壳聚糖能调节实验性高脂血症大鼠血脂代谢,抑制肝脏脂肪沉积,有良好的降脂保肝作用,其作用与脱乙酰程度呈正相关.
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| 关 键 词： | 蝇蛆壳聚糖 脱乙酰度 实验性高脂血症 降脂保肝 |
Research of housefly maggot chitosan on lowering lipid and hepatoprotective effect |
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| QIN Rong-Gui,WU Jian-Wei,GUO Guo,et al..Research of housefly maggot chitosan on lowering lipid and hepatoprotective effect[J].Chinese Journal of Gerontology,2010,30(7). |
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| Authors: | QIN Rong-Gui WU Jian-Wei GUO Guo |
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| Institution: | QIN Rong-Gui,WU Jian-Wei,GUO Guo,et al.Department of Pharmacognosy,Pharmaceutical College,Guiyang Medical University,Guiyang 550004,Guizhou,China |
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| Abstract: | Objective To study effects of degree of deacetylation of housefly maggot chitosan (HMC) on lowering lipid and hepatoprotective action.Methods The chemical method was used to prepare deacetylated HMC of 72.3%, 80.5%, 96.1% and infrared scanning was used to identify its structure. The rats were fed with high cholesterol diet and were administrated different deacetylation HMC continuously for 8 weeks at the same time, then the blood lipid were measured. The liver weight (LW), liver index (LI) and cholesterol c... |
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| Keywords: | Housefly maggot chitosan Deacetyiation Hypercholesterolemia Lowering lipid and hepatoprotective effect |
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