系统性红斑狼疮合并代谢综合征的相关因素

目的 探讨系统性红斑狼疮(SLE)合并代谢综合征(MS)的发病情况及相关因素.方法 收集SLE患者120例,根据是否伴有MS分为MS组和非MS(NMS)组.采用x2检验、t检验和Mann-WhitneyU检验比较两组体质量指数(BMI)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)等相关临床指标.结果 SLE患者的MS发生率为23.3％(28/120),MS组BMI、TC、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、24小时尿蛋白、空腹血糖(FPG)、C反应蛋白(CRP)及损伤指数(SDI)均高于NMS组,HDL-C低于NMS组,分别为BMI 26.8±3.7 vs 21.2±3.3、TC(5.8±2.1) mmol/L vs (4.9±1.5) mmol/L、TG 2.2(1.6) mmol/L vs 1.5(1.2) mmol/L、LDL-C(3.8±1.8) mmol/Lvs (2.9±1.3) mmol/L、24小时尿蛋白927.0(3 775.9) mg vs 325.2(689.6)mg、FPG 5.8(2.1) mmol/L vs 4.6(1.4)mmol/L、CRP 7.4(9.1) mmol/L vs 5.3(7.3) mmol/L、SDI 1.0(1.0) vs 0(1.0),HDL-C(1.1±0.4) mmol/L vs (1.3±0.4) mmol/L(P＜0.05或＜0.01).结论 SLE合并MS患者的高血压、高血糖、血脂紊乱及肥胖发生率较高,SLE患者的肾损害及持续的炎症反应可能参与了MS的发生.

Factors associated with metabolic syndrome in systemic lupus erythematosus

Objective To investigate prevalence of metabolic syndrome（MS） and its related factors in patients with systemic lupus erythematosus（SLE）. Methods A total of 120 patients with SLE were evaluated and divided into MS group and non-MS group. Relevant clinical indicators of the two groups such as body mass index（BMI）, total cholesterol（TC） ,high density lipoprotein cholesterol（HDL-C）, and so on were analyzed by chi-square test, Students＇ t test and Mann-Whitney test. Results The prevalence of MS was 23.3% （28/120）. MS group and non-MS group showed significant differences in BMI, TC, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, proteinuria, fasting blood glucose（FBG）, C-reactive prote~n（CRP） and Systemic Lupus International Collaborating Clinics/ACR damage index（SDI） in MS group were lower than those in NMS group, HDL-C was higher than NMS group. BMI 26.8± 3.7 vs 21.2±3.3,TC（5.8±2.1） mmol/L vs （4.9±1.5） mmol/L,TG 2. 2（1.6） mmol/L vs 1.5（1.2） mmol/L,LDL-C （3.8 ± 1.8） mmol/L vs （2.9 ± 1.3） mmol/L, proteinuria 927.0 （3 775.9） mg vs 325.2 （689.6） mg, FPG 5.8 （2.1） mmol/L vs 4.6（1.4） mmol/L,CRP 7.4（9.1） mmol/L vs 5.3（7.3） mmol/L,SDI 1.0（1.0） vs 0（1.0）,HDL-C（1.1±0.4） mmol/L vs （1.3±0.4） mmol/L（ P 〈0.05 or 〈0.01）. Conclusion Morbidity of hypertension,hyperglycemia, dyslipidemia and obesity are higher in SLE patients with MS, kidney damage and continuous inflammation response involved in the occurrence of MS.