内质网应激在年龄相关性黄斑变性中的作用

内质网是哺乳动物细胞内蛋白质加工的重要细胞器,各种因素导致的内质网应激(ERS)过强均可能损伤细胞功能,甚至引起细胞死亡.年龄相关性黄斑变性(AMD)是多因素导致的常见致盲性疾病,研究证实氧化应激、炎症反应及脂代谢异常等因素引起的ERS在AMD的发生发展过程中起重要作用,其中促使视网膜色素上皮(RPE)中血管内皮生长因子(VEGF)表达上调,进而促进脉络膜新生血管(CNV)长入Bruch膜而形成CNV膜是干性AMD转变为湿性AMD的主要病理机制.就ERS的发生过程、发生机制及氧化应激、炎症反应等因素与ERS在AMD病变过程中的相互作用进行综述.

Research progress in the effect of endoplasmic reticulum stress on age-related macular degeneration

The endoplasmic reticulum is a major organelle of mammalian cells in where protein processing takes place. Excessive endoplasmie reticulum stress （ERS） induced by various factors may lead to cellular structural abnormality and functional dysfunction,even cell death. Age-related macular degeneration （AMD）is caused by multi- factors and is a common cause of blindness. Inducers of ERS, such as oxidative stress,inflammation and disorder of fat metabolism,have been found to play critical role in AMD. These factors promote the excess expression of vascular endothelial growth factor （VEGF）in retinal pigment epithelium （RPE）, which is the key factor that triggers the conversion from dry AMD to wet form. This article mainly summarized the primary process and mechanism of ERS as well as interactions among oxidative stress,inflammation and ERS in AMD pathogenesis.