| FK506血药浓度与糖代谢相关血液指标的观察 |
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| 引用本文： | 董矜,王玲,田亚平,刘红鹰,姜辉.FK506血药浓度与糖代谢相关血液指标的观察[J].军医进修学院学报,2006,27(6):466-467. |
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| 作者姓名： | 董矜 王玲 田亚平 刘红鹰 姜辉 |
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| 作者单位： | 解放军总医院生化科,北京,100853 |
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| 摘 要： | 目的:探讨长期服用FK506(tacrolimus)患者血中糖代谢指标与血药浓度的关系。方法:FK506血药浓度用微粒子酶免疫分析法,糖化血红蛋白(HbA1)用液相色谱法,血糖(G lu)、糖化血清蛋白(GSP)、白蛋白(A1b)用罗氏公司试剂盒,红细胞(Rbc)、血红蛋白含量(HGB)在雅培Cell Dyn 3200血细胞仪上测定。结果:男性GSP、HGB明显高于女性;不同年龄组仅有GSP明显差异;FK-506不同浓度组A lb、HbA1、RBC、HGB有统计学差异(P<0.05)。结论:HbA1和GSP可作为临床参考指标,用于检测FK-506浓度改变引起的糖代谢紊乱,并调整用药。
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| 关 键 词： | FK506 葡萄糖 糖化血清蛋白 糖化血红蛋白 血药浓度 |
| 文章编号： | 1005-1139（2006）06-0466-02 |
| 收稿时间： | 2006-01-19 |
| 修稿时间： | 2006-04-06 |
Effect of FK506 on the metabolism of glucose in blood |
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| DONG Jin,WANG Ling,TIAN Ya-ping,LIU Hong-ying,JIANG Hui.Effect of FK506 on the metabolism of glucose in blood[J].Academic Journal of Pla Postgraduate Medical School,2006,27(6):466-467. |
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| Authors: | DONG Jin WANG Ling TIAN Ya-ping LIU Hong-ying JIANG Hui |
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| Institution: | Clinical Biochemistry Department of PLA General Hospital, Beijing 100853, China |
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| Abstract: | Objective:To investigate changes glucose metabolism-related markers in blood by a long-term intaken FK506(tacrolimus).Methods:tacrolimus blood levels were measured by MEIA method;HbA1 was measured by high performance liquid chromatography;red blood cells and HGB were performed on Abbott cell dyn 3200 analyzer;other tests were processed on abbott Ci8200 analyzer with relevant reagent kits.Result:GSP and HGB are higher in male;GSP has significant changes by age;Alb/HBA1/RBC/HGB values changes with different tacrolimus blood level;Conclusion:HbA1 and GSP are good markers for monitoring of glucose metabolism confusion and posttransplant diabetes mellitus. |
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| Keywords: | tacrolimus glucose glycosylated hemoglobin(HBA1) glycated serum protein(GSP) plasma concentration |
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