| 系统性红斑狼疮T细胞TCR/CD3信号转导异常的研究进展 |
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| 引用本文： | 游弋,郝飞. 系统性红斑狼疮T细胞TCR/CD3信号转导异常的研究进展[J]. 免疫学杂志, 2005, 21(Z1): 54-56 |
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| 作者姓名： | 游弋 郝飞 |
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| 作者单位： | 第三军医大学西南医院皮肤科,重庆,400038 |
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| 摘 要： | T细胞受体/CD3复合体(TCR/CD3)与抗原呈递细胞(APC)表面的组织相容复合物(MHC)-抗原肽发生交连是T细胞特征性识别抗原,活化细胞、传导信号并发生抗原特异免疫反应的重要起始途.系统性红斑狼疮T细胞TCR/CD3信号传导异常是T细胞免疫功能障碍的基础.本文就系统性红斑狼疮T细胞TCR/CD3信号转导异常的研究进展作一综述.
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| 关 键 词： | 系统性红斑狼疮 TCR/CD3 TCR-ζ链 |
| 文章编号： | 1000-8861(2005)03(S)-0054-03 |
| 修稿时间： | 2005-02-01 |
Advances in the research of the abnormal TCR/CD3-mediated signaling in SLE T cells |
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| YOU Yi. Advances in the research of the abnormal TCR/CD3-mediated signaling in SLE T cells[J]. Immunological Journal, 2005, 21(Z1): 54-56 |
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| Authors: | YOU Yi |
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| Abstract: | The direct interaction of the TCR/CD3 complex with the major histocompability complex on antigen-presenting cells plays a key role in antigen recogmtion, T cell activation, and consequence in triggering an antigen specific immune response. Accumulating evidence suggest that potential defects of the T cell functional of systemic lupus erythematosus ( SLE) resides in the proximal abnormal signal transduction around the TCR-CD3 complex. This article summarizes the recent information about the abnormal TCR/CD3-mediated signaling in SLE T cells. |
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