原发性高血压患者血清非对称性二甲基精氨酸的测定及临床意义的研究

目的探讨血清非对称性二甲基精氨酸(ADMA)与原发性高血压(EH)的关系及其临床意义。方法选择62例EH患者和24例健康体检者,分别测定血清中ADMA和一氧化氮(NO)水平并进行比较。结果EH组与对照组的血清ADMA、NO水平间差异有统计学意义(P<0.01)。对照组与高血压各亚组患者的血清ADMA水平间差异均有统计学意义(P<0.01);高血压Ⅰ期组与高血压Ⅱ、Ⅲ期组的血清ADMA水平间差异有统计学意义(P<0.05);高血压Ⅱ期组与Ⅲ期组的血清ADMA水平间差异有统计学意义(P<0.01)。结论ADMA的异常增高可能与EH发病有关;EH患者血清ADMA水平随病情的加重而增加。

Changes of Plasma Asymmetric Dimethylarginine Level in Patients with Essential Hypertension and Its Clinical Significance

Objective To investigate the endogenous inhibitor of nitric oxide synthase(NOS) asymmetric dimethylarginine(ADMA) in patients with essential hypertension(EH) and its clinical significance.Methods Patients were randomly divided into two groups:EH group (n=62) and a normal control group (n=24).Levels of ADMA and NO in serum were measured.Results The level of NOS inhibitor ADMA was significantly increased in the EH group compared with that in control group(P<0.01); The level of NO was significantly decreased in the EH group (P<0.01); The endogenous ADMA increased significantly with aggravation of essential hypertension in the EH group (P<0.05).Conclusion The abnormal increase of endogenous NOS inhibitor of ADMA is correlated with the occurrence of EH.An increasing level of ADMA may be one of the risk factors that should be paid attention to.