The effect of ranitidine, cimetidine or famotidine on low-dose post-prandial alcohol absorption |
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Authors: | A. G. FRASER E. J. PREWETT M. HUDSON A. M. SAWYERR S. B. ROSALKI R. E. POUNDER |
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Affiliation: | University Department of Medicine, Royal Free Hospital School of Medicine, London, UK. |
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Abstract: | Plasma alcohol concentration following oral ingestion of 0.3 g/kg of alcohol (ethyl alcohol), one hour after an evening meal, was measured in four groups of 12 healthy subjects. Each group had a control study and a repeat study after 7 days dosing with either placebo or an H2-receptor antagonist (300 mg ranitidine nocte, 800 mg cimetidine nocte, or 40 mg famotidine nocte). There was no significant difference between the control and post-dosing studies in the integrated 4-h plasma alcohol concentration, peak plasma alcohol concentration, or time to reach peak alcohol concentration. This study shows that post-prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine. |
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