蛋白翻译起始因子C2在结、直肠癌中表达的意义

目的　研究C2基因在结、直肠癌中的表达、分布及意义 .方法　用免疫组化方法检测C2基因在 6 2例结肠癌及其4 6例癌旁组织、4 6例直肠癌及其 30例癌旁组织中蛋白水平的表达 .结果　结肠癌 6 2例中C2蛋白阳性率为 4 1.9% (2 6 /6 2 ) ,4 6例其癌旁组织中 ,C2蛋白阳性率为 82 .6 % (38/46 ) .C2蛋白在结肠癌组织中表达明显低于其癌旁组织 (P <0 .0 5 ) ,且与结肠癌组织的浆膜浸润、淋巴结转移有明显的相关性 (P <0 .0 5 ) .直肠癌 4 6例中C2蛋白阳性率为 4 3.5 % (2 0 /46 ) ,30例其癌旁组织中 ,C2蛋白阳性率为 73.3% (2 2 /30 ) .C2蛋白在直肠癌及其癌旁组织中的表达无明显差异(P >0 .0 5 ) .结论　C2基因表达缺失及突变可能与大肠癌的发生、发展有关 .

Expression significance of translation initiation factor C2 gene in colorectal cancer tissue

AIM To study the distribution, expression and significance of C2 gene in colorectal cancer tissue. METHODS ABC immunohistochemical method was used to detect the expression of C2 protein in 62 samples of colon cancer tissue and 46 samples of their pericancerous tissue, as well as 46 samples of rectal cancer tissue and 30 samples of their pericancerous tissue. RESULTS In the 62 samples of colon cancer tissue and 46 samples of their pericancerous tissue, the positive rates of C2 protein were 41.9% and 82.6%, respectively. Statistical analysis suggested that the positive rates of C2 protein were significantly higher in their pericancerous tissue than that in colon cancer tissue ( P <0.05). C2 protein was significantly correlated with the depth of invasion and lymph node metastases ( P <0.05). In the 46 samples of rectal cancer tissue and 30 samples of their pericancerous tissue, the positive rates of C2 protein were 43.5% and 73.3%, respectively. Statistical analysis suggested that the positive rates of C2 protein had no significant difference in rectal cancer tissue and their pericancerous tissue ( P >0.05). CONCLUSION Low expression or mutation of C2 protein may play an important role in the development of colorectal cancer tissue.