蘑菇伞封堵器封堵动脉导管未闭前后心脏内分泌改变

目的 观察蘑菇伞封堵器封堵动脉导管未闭(PDA)后心脏内分泌功能的改变。 方法 对33例单纯PDA患儿应用蘑菇伞封堵器封堵前、封堵后1~2天和封堵后4~6周分别进行血浆心钠素(ANP)、心指数(CI)和钠排泄分数(FENa％)测定分析。 结朵 33例患儿封堵前血浆心钠素明显高于正常对照组(P<0.05),封堵后1~2天血浆心钠素又有增高且明显高于封堵前和正常对照组(P<0.05)。心指数在封堵前明显低于正常对照组和封堵后4~6周(P<0.05)。钠排泄在封堵后1~2天明显增加(P<0.05)。血浆心钠素、心指数和钠排泄分数在封堵后4~6周与正常对照组比较差别无显著意义(P>0.05)。 结论 蘑菇伞封堵器封堵PDA不会改变心脏内分泌活动,相反通过纠正异常通道,使心脏内分泌活动恢复正常。

Transcatheter closure of Amplatzer occluders in the PDA patients

Objective To observe cardiac endocrinology changes in the PDA patients treated by transcatheter closure of Amplatzer occluders. Methods 33 PDA patients underwent the measurements of the plasma natriurtic polypetide(pANP) , cardiac index (IC) and fraction execretion natrium(FENa%) in different phase of the treatment by using the transcatheter closure of Amplatzer occluders (before , post 1-2 day and 4 - 6 weeks). Results The level of pANP in 33 PDA patients before the transcatheter closure were significantly higher than the normal (P< 0.05).After the transcatheter closure 1-2 days the level of pANP got even more higher than the former and the normal (P< 0.05).The level of CI were significantly lower.The fraction execretion natrium(FENa%) jumped higher after the transcatheter closure 1-2 days,and went down to normal within 4-6 weeks. All the pANPIC and execretion natrium got normal after transcatheter closure 4 - 6 weeks. Conclusion The Amplatzer occluder will not change the cardiac endocrinology, on the contrary, it can correct the abnormality of the heart .