伊班膦酸钠治疗恶性肿瘤骨转移疼痛临床观察

目的: 观察伊班膦酸钠治疗恶性肿瘤骨转移所致骨痛及活动功能障碍的疗效。方法: 35例各类恶性肿瘤骨转移患者,应用伊班膦酸钠2 mg静脉滴注,2~4周1次,其中25例配合化、放疗治疗。结果: 骨痛控制有效率85%(30/35),其中以乳腺癌和多发性骨髓瘤疗效较好,配合化、放疗者较单独用药者更佳;治疗后77%(27/35)的患者活动功能有改善。3例获影像学完全缓解。结论: 伊班膦酸钠能有效缓解恶性肿瘤骨转移所致骨痛及改善活动功能障碍。

Sodium ibandronate in treatment of metastatic bone diseases caused by cancer

Objective:To observe the effect of sodium ibandronate on bone pain and ameliorating physical motion of cancer patients with bone metastases.Methods:Thirty-five cancer patients with bone metastases were administrated 2 mg AIBEN every 2 to 4 weeks and twenty-five cases received chemotherapy or radiation.Results:The total effective rate of bone pain relief was 85% (30/35),with better results for breast cancer and multiple myeloma.The effect was more obvious when accompanied by chemotherapy or radiation.Seventy-seven 77% of the cases obtained good physical motion and 3 cases demonstrated complete response on screening.Conclusions:Ibandronate can effectively relieve bone pain caused by neoplasm metastasis and improve the physical motion of the patients.