一种新的心肌声学造影技术:持续静脉滴注声振微泡的心肌声学造影方法研究

目的；探讨持续静脉滴注法行心肌声学造影的安全性及有效性。方法：经犬外周静脉持续注微泡造影剂动态观察心肌显效果及其对血流动力学的影响。结果：２ｍｌ／ｍｉｎ和６ｍｌ／ｍｉｎ滴注组分别于滴注后约７２．７秒和１９．９秒心肌开始显影，持续到滴注停止后约半分钟心肌显影消退。前降支套扎及再灌注过程中可观察到局部心肌声学造影充填，缺损、再充填的动态演变。全部造影过程中无血流动力学及心电图变化。结论：持续静脉滴注法

Experimental Study of Myocardial Contrast Echocardiography by Continuous Injection of Sonicated Microbubbles:A Novel Methodological Research

Objective:To investigate the safety and efficacy of continuous injection of sonicated microbubbles for myocardial contrast echocardiography(MCE).Methods:To detect the contrast effect anf cardiac hemodynamics during continuous injection of contrast agent through femoral vein in 7 dogs.Results:Myocardial contrast effect appeared after 72 7 seconds and 19 9 seconds continuous injection at velocity of 2 ml/min and at 6 ml/min respectively.The contrast effect lasted about 30 sec.Contrast defect and reperfusion at LAD territory were demonstrated during LAD occlusion and release..No adverse effect with hemodynamics and ECG were found.Conclusion:MCE continuous infusion of sonicated microbubbles is a method of safety and efficacy for evaluating myocardial perfusion.