慢性乙型肝炎患者血液流变学的研究

目的　探讨慢性乙型肝炎 (慢性乙肝 )患者血液流变学的改变 ,并分析其与患者HBVDNA、肝功能、氧化损伤各项指标间的关系。方法　检测 5 5例慢性乙肝患者血液流变学指标、氧化损伤指标、肝功能、HBVDNA ,并对此做出相关分析。结果　乙肝组与正常对照组比较 :全血低切粘度、红细胞聚集指数均有明显升高 (P <0.0 5 )。ALT异常组与正常组及正常对照组比较 :红细胞压积、全血低切粘度、红细胞聚集指数均有明显升高 (P <0 .0 5 )。HBVDNA阳性组与阴性组比较差异无统计学意义 (P >0.0 5 )。血液流变学指标和氧化损伤指标间无相关关系 (P >0.0 5 )。结论　慢性乙肝患者体内存在微循环障碍及氧化损伤 ,血液流变学及氧化损伤指标与HBVDNA是慢性乙肝患者检查中相对独立的指标

Hemorheologic changes in patients with chronic hepatitis B

Objective To study the variation of the hemorheology in patients with chronic hepatitis B and study its relations with HBV DNA, liver function and oxidative stress markers. Methods Indices for hemorheology, oxidative stress markers, liver function, and HBV DNA were measured in 55 patients with chronic hepatitis B and correlative analysis was made. Results The low-shear whole blood viscosity (BV), RBC aggregation index were significantly higher in hepatitis B group than those in the control group (P<0.05), Hematocrit (HCT), the low-shear BV, RBC aggregation index were significantly higher in the patients whose ALT was higher than the patients whose ALT was normal and the controls. No significant difference was found in HBV DNA and indices of hemorheology(P>0.05), nor in indices of hemorheology and oxidative stress markers (P>0.05). Conclusion There is disturbance of microcirculation and oxidative stress in the body of patients with chronic hepatitis B. The hemorheology and oxidative stress markers should be regarded as useful indexes in patients with chronic hepatitis B in addition to HBV markers.