Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines |
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| Authors: | Huo-Jian Wang Cheng-Xi Wei Xian-Qing Deng Fu-Lan Li Zhe-Shan Quan |
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| Affiliation: | 1. Institute of Neurosurgery, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region, P.R. China College of Pharmacy, Yanbian University, Yanji, Jilin, P.R. China. Fax: +86 433 266-0568;2. College of Pharmacy, Yanbian University, Yanji, Jilin, P.R. China. Fax: +86 433 266-0568 |
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| Abstract: | Several 5-alkoxy-tetrazolo[1,5-a]quinazoline derivatives have been synthesized by reacting 2,4-dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS, 1H-NMR, and elementary analysis. Anticonvulsant activities were evaluated using the maximal electroshock (MES) test. Most of the synthesized compounds displayed weak anticonvulsant activity at a dose of 300 mg/kg. Antidepressant activities were investigated by forced swimming test. Two compounds, namely 5-(hexyloxy)tetrazolo[1,5-a]quinazoline and 5-(4-methoxyphenoxy)tetrazolo[1,5-a]quinazoline, showed significant antidepressant activity, which decreased the immobility time by 62.2 and 51.7% at 100 mg/kg dose level. |
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| Keywords: | Anticonvulsant Antidepressant Forced swimming test Quinazoline Tetrazole |
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