Acupuncture for the treatment of sudden sensorineural hearing loss: A systematic review and meta-analysis: Acupuncture for SSNHL |
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| Institution: | 1. Anhui Medical University, No. 81 MeiShan Road, Hefei, AnHui, People’s Republic of China;2. Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230032, Anhui, People’s Republic of China;1. School of Health Science Blanquerna, Ramon Llull University, Barcelona, Spain;2. Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;3. Faculty of Health Science and Welfare, University of Vic, Vic, Spain;4. Residència Jaume Batlle, Pere Mata Foundation, Barcelona, Spain;5. Global Research on Wellbeing (GRoW) Research Group, Ramon Llull University, Barcelona, Spain;1. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;2. Department of Dermatology, Shaanxi Traditional Chinese Medicine Hospital, Xi`an, 710003, China;3. Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China;4. Department of Pathology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;5. Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 02118, USA;1. School of Public Health, Evidence-Based Social Science Research Center, Lanzhou University, Lanzhou, China;2. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China;3. Evidence Based Social Science Research Center, Lanzhou University, Lanzhou, China;4. Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China;5. Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China;6. Gansu University of Chinese Medicine, Lanzhou, China;7. The First Hospital of Lanzhou University, Lanzhou, China;1. Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan;2. School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan;3. Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan;4. School of Medicine, Tzu-Chi University, Hualien, Taiwan;5. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan;1. The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China;2. Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China |
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| Abstract: | BackgroundAcupuncture as an alternative treatment method is widely used in the treatment of sudden sensorineural hearing loss(SSNHL) in China. We performed a systematic review and meta-analysis to assess the clinical efficacy of acupuncture for the management of SSNHL patients.Materials and MethodsThe PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure and WanFang databases were searched. Searches were performed on April 27, 2018 and without language and publication year restrictions. We collected and analyzed the randomized controlled trials (RCTs) of acupuncture for the treatment of SSNHL patients to assess its efficacy and safety. The RevMan5.3 software was used for analysis. The fixed-effects model can be applied to calculate the risk ratio (RR) or weighted mean difference (WMD) if the chi-square test shows there was no significance of heterogeneity (p > 0.10, I2<50%). Otherwise, the random effects mode was used.ResultsTwenty randomized controlled trials met our inclusion criteria. The electroacupuncture(EA), manual acupuncture(MA) plus western medicine(WM) and EA plus WM groups lead to significantly better pure tone audiometry(PTA) than WM alone in cured rate (P = 0.01; P < 00,001; P < 0.006, respectively). However, no significant differences were observed between MA and WM (p = 0.27). In terms of total effective rate, all of them showed significant improvement compared to WM alone (MA: P = 0.03; EA: P = 0.01; MA + WM: P < 0.00001; EA + WM: P = 0.04). In addition, no significant difference was found between the MA plus WM and WM alone groups in the improvement of tinnitus (P = 0.37). No trials reported serious adverse events.ConclusionAcupuncture could be a valid treatment option for SSNHL, especially for patients who could not be cured by drugs alone. However, the outcome was limited temporarily due to the lack of high-quality research support. High-quality evidence is needed to clarify the future efficacy and safety of acupuncture for SSNHL. |
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| Keywords: | Acupuncture Meta-analysis Hearing loss Sudden |
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