Influence of posture on blink reflex prepulse inhibition induced by somatosensory inputs from upper and lower limbs |
| |
| Institution: | 1. Department of Neurorehabilitation, Hospital of Vipiteno/Sterzing, Vipiteno, Sterzing, Italy;2. Reasearch Unit for Neurorehabilitation of South Tyrol, Bolzano, Bozen, Italy;3. Department of Neurology, Hochzirl Hospital, Zirl, Austria;4. EMG and Motor Control Unit, Department of Neurology, Hospital Clínic, Barcelona, Spain;5. IDIBAPS (Institut d''Investigació August Pi i Sunyer), Facultat de Medicina, University of Barcelona, Barcelona, Spain;1. Faculty of Health Sciences, Univeristy of Malta, Msida, Malta;2. Faculty of Health Sciences, University of Malta, Msida, Malta;1. Research and Development Section, Department of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA;2. DoD-VA Extremity Trauma and Amputation Center of Excellence, USA;3. Department of Surgery, Uniformed Services University of the Health Sciences & Walter Reed National Military Medical Center, Bethesda, MD, USA;4. Department of Rehabilitation Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;1. Graduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo, Brazil;2. Biomechanics and Motor Control Laboratory, School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Brazil;3. Center of Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Brazil;1. São Paulo State University (UNESP), Human Movement Research Laboratory (MOVI-LAB), Graduate Program in Movement Science, Department of Physical Education, Bauru, SP, Brazil;2. São Paulo State University (UNESP), Laboratory of Information, Vision and Action (LIVIA), Graduate Program in Movement Science, Department of Physical Education, Bauru, SP, Brazil;3. Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA;1. Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA;2. Human Movement Research Laboratory (MOVI-LAB), Department of Physical Education, São Paulo State University (UNESP), Bauru, São Paulo, Brazil |
| |
| Abstract: | BackgroundPrepulse inhibition (PPI) is a neurophysiological phenomenon whereby a weak stimulus modulates the reflex response to a subsequent strong stimulus. Its physiological purpose is to avoid interruption of sensory processing by subsequent disturbing stimuli at the subcortical level, thereby preventing undesired motor reactions. An important hub in the PPI circuit is the pedunculopontine nucleus, which is also involved in the control of posture and sleep/wakefulness.ObjectiveTo study the effect of posture (supine versus standing) on PPI, induced by somatosensory prepulses to either upper or lower limb. PPI was measured as the percentage inhibition of the blink reflex response to electrical supraorbital nerve (SON) stimulation.MethodsSixteen healthy volunteers underwent bilateral blink reflex recordings following SON stimulation either alone (baseline) or preceded by an electrical prepulse to the median nerve (MN) or sural nerve (SN), both in supine and standing. Stimulus intensity was 8 times sensory threshold for SON, and 2 times sensory threshold for MN and SN, respectively. Eight stimuli were applied in each condition.ResultsBaseline blink reflex parameters did not differ significantly between the two postures. Prepulse stimulation to MN and SN caused significant inhibition of R2. In supine but not in standing, R2 was significantly more inhibited by MN than by SN prepulses. In standing, SN stimulation caused significantly more inhibition of R2 than in supine, while the inhibition caused by MN prepulses did not differ significantly between postures.SignificancePPI induced by lower limb afferent input may contribute to postural control while standing. |
| |
| Keywords: | Standing posture Supine posture Blink reflex Prepulse inhibition Somatosensory prepulse |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
