| Affiliation: | 1. Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania;2. Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania;3. The Rothman Institute of Orthopaedics, Thomas Jefferson University, Philadelphia, Pennsylvania;4. Center for Bioactive Materials and Tissue Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania |
| Abstract: | Peri-prosthetic infection remains a serious complication of joint replacement surgery. Herein, we demonstrate that a vancomycin-containing sol-gel film on Ti alloy rods can successfully treat bacterial infections in an animal model. The vancomycin-containing sol-gel films exhibited predictable release kinetics, while significantly inhibiting S. aureus adhesion. When evaluated in a rat osteomyelitis model, microbiological analysis indicated that the vancomycin-containing sol-gel film caused a profound decrease in S. aureus number. Radiologically, while the control side showed extensive bone degradation, including abscesses and an extensive periosteal reaction, rods coated with the vancomycin-containing sol-gel film resulted in minimal signs of infection. µCT analysis confirmed the radiological results, while demonstrating that the vancomycin-containing sol-gel film significantly protected dense bone from resorption and minimized remodeling. These results clearly demonstrate that this novel thin sol-gel technology can be used for the targeted delivery of antibiotics for the treatment of periprosthetic as well as other bone infections. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 701–709, 2009 |
