C/EBP homologous protein investigation in the serum and cerebro-spinal fluid of relapsing-remitting multiple sclerosis patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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C/EBP homologous protein investigation in the serum and cerebro-spinal fluid of relapsing-remitting multiple sclerosis patients

Institution:	1. Department of Clinical Biochemistry, AJA University of Medical Sciences, Tehran, Iran;2. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;3. Department of Clinical Biochemistry, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran;4. Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Clinical Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran;1. Department of Pediatric Neurology, Gazi University Faculty of Medicine, 10th Floor Besevler, Ankara, Turkey;2. Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey;1. Department of Interventional Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China;2. Department of Emergency, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China;3. Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China;1. Department of Medicine, University of Alabama at Birmingham, Birmingham, Ala;2. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Ala;3. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Ala;4. Department of Pathology, University of Alabama at Birmingham, Birmingham, Ala;5. Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Ala;6. Department of Surgery, University of Alabama at Birmingham, Birmingham, Ala;7. Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Ala;8. Comprehensive Arthritis, Musculoskeletal and Autoimmunity Center, University of Alabama at Birmingham, Birmingham, Ala

Abstract:	The exact determination of endoplasmic reticulum (ER) stress-associated proteins is not completely elucidated in the multiple sclerosis (MS) patients. We measured CHOP concentrations in the serum and cerebro-spinal fluid (CSF) of relapsing-remitting MS (RRMS) patients (n = 20) in comparison with the non-MS control group (n = 20) to determine whether this marker could be detected in the body fluids of RRMS patients. CHOP marker was not detectable in all harvested CSF samples. However, its levels were detectable in all serums harvested from both non-MS and RRMS patients and its levels in the latter group were not significantly higher than those of the non-MS control group (P value = 0.265). CHOP was not detectable in the CSF of RRMS patients in spite of the recent reports on the RRMS autopsies. Additionally, there were not any significant correlations (Spearman's correlation) between both of EDSS score and age with CHOP serum concentrations in all subjects.

Keywords:	CHOP Endoplasmic reticulum stress Relapsing remitting multiple sclerosis Unfolded protein response
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