Chinese herbal medicine reduces acute hepatitis exacerbation in patients with hepatitis B virus infection: A case-control study in Taiwan |
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| Affiliation: | 1. Department of Traditional Chinese Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;2. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;3. Department of Public Health, Fu-Jen Catholic University, New Taipei, Taiwan;4. Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan;5. School of Medicine, National Defense Medical Center, Taipei, Taiwan;6. Department of Nursing, Hungkuang University, Taichung, Taiwan;1. Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, Spain;2. Motion in Brains Research Group, Instituto de Neurociencias y Ciencias del Movimiento (INCIMOV), Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, Madrid, Spain;3. Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Universidad de León, Av. Astorga, s/n, Ponferrada, 24401, León, Spain;4. Hospital La Paz Institute for Health Research, IdiPAZ, Madrid, Spain;1. CARE Program, Dept of Pediatrics, University of Alberta, Edmonton, Alberta, Canada;2. CARE Program, Dept of Pedaitric, University of Alberta, Edmonton, Canada;3. College of Medicine, Ohio State University, Columbus, OH, 43210, United States;4. Dept of Pediatrics, St Antonius Hospital, Nieuwegein, The Netherlands;5. Dept of Pediatrics Kiboga District Government Hospital, Uganda;1. University of Milwaukee, College of Nursing, 1921 E Hartford Ave, Milwaukee, WI, 53211, USA;2. University of South Alabama, Department of Health, Kinesiology and Sport, 171 Jaguar Drive, Mobile, AL, 36688-0002, USA;1. School of Psychology, University of Ottawa, Ontario, Canada;2. School of Human Kinetics, University of Ottawa, Ontario, Canada;1. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;2. Harvard Medical School, USA |
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| Abstract: | ObjectivesLittle information is available about the impact of Chinese herbal medicine (CHM) treatment on acute exacerbation of hepatitis. This study aimed to assess the risk of acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma in HBV patients with and without CHM use.Design and settingThis population-based case-control study used data from the Taiwan Longitudinal Health Insurance Database from 2000 to 2013. Newly diagnosed HBV patients had acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma as the case group, while another patients had no acute exacerbation of hepatitis and cirrhosis and hepatoma as the control group. To correct the differences in sociodemographic factors and Western medication use between the two groups, propensity score matching was used at a 1:1 ratio, and resulted in a comparison of 1306 and 805 patients per group, respectively.Main outcome measuresOccurrence of acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma.ResultsOverall rate of acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma was 7.9% and 4.8%, respectively. Patients receiving CHM had a significantly lower risk of acute exacerbation of hepatitis (adjusted odds ratio [aOR] =0.20, 95% confidence interval [95%CI]: 0.13–0.31) and subsequent cirrhosis and hepatoma (aOR = 0.29, 95%CI: 0.18–0.49) than those not receiving CHM after adjusting for relevant covariates. However, no dose-dependent relationship was exhibited for either incidence of acute exacerbation of hepatitis and cirrhosis and hepatoma.ConclusionThese findings highlight that the use of CHM was associated with a significantly reduced risk of acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma in patients with HBV. Future research could further explore the benefit of CHM therapies for treatment of acute hepatitis exacerbation. |
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| Keywords: | Acute hepatitis exacerbation Case-control study Chinese herbal medicine Hepatitis B virus infection |
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