Clinical evidence of Chinese medicine therapies for depression in women during perimenopause and menopause |
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| Affiliation: | 1. The China-AustraliaInternational Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia;2. Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China;1. Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China;2. Acupuncture and Tuina School, Shaanxi University of Chinese Medicine, Xi’an, Shaanxi, China;3. Graduate school, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China;1. School of Health Science Blanquerna, Ramon Llull University, Barcelona, Spain;2. Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China;3. Faculty of Health Science and Welfare, University of Vic, Vic, Spain;4. Residència Jaume Batlle, Pere Mata Foundation, Barcelona, Spain;5. Global Research on Wellbeing (GRoW) Research Group, Ramon Llull University, Barcelona, Spain;1. Experimental Pathology Institute, Faculty of Medicine, University of Coimbra, Portugal;2. Biophysics Institute, Faculty of Medicine, University of Coimbra, Portugal;3. Institute of Integrated Clinical Practice, Dentistry Department, Faculty of Medicine, University of Coimbra, Portugal;4. Coimbra Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal;5. CNC.IBILI Consortium, University of Coimbra, Portugal;6. Radiation Oncology Department, Coimbra University Hospital Centre, Portugal;7. Coimbra Chemistry Centre, Faculty of Sciences and Technology, University of Coimbra, Portugal;1. School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Gynecology and Obstetrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Chinese and Complementary Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | BackgroundDepression is common in women during perimenopause and menopause. Complementary therapies such as acupuncture and Chinese herbal medicine (CHM) are often utilized by these women. However, the efficacy and safety of these treatments have not been systematically evaluated.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). Nine English and Chinese databases were searched and search terms included perimenopause, menopause, depression, Chinese herbal medicine, acupuncture, RCTs, and their synonyms. Methodological quality was assessed using the Cochrane Risk of Bias Tool.ResultsA total of 18 RCTs were identified (6 CHM, 11 acupuncture related therapies, 1 combination of CHM and acupuncture). For Hamilton Rating Scale of Depression (HRSD) and Kuppermans Index of Menopause, tuina-massage, combined therapy of CHM plus acupuncture showed significant benefits at end of treatment compared to antidepressants. Either CHM and acupuncture reduced HRSD scores, indicating less severe depression, showing comparable effects to antidepressants.ConclusionCHM and acupuncture treatment in perimenopause and menopausal women resulted in reduced severity of depression. Results should be interpreted with caution given the small number of studies included in this review and further RCTs are warranted to validate findings from this review. |
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| Keywords: | Depression Menopause Perimenopause Chinese herbal medicine Acupuncture Review |
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