Effects of pro-/synbiotic supplementation on anthropometric and metabolic indices in overweight or obese children and adolescents: A systematic review and meta-analysis |
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| Affiliation: | 1. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;2. Halal Research Center of IRI, FDA, Tehran, Iran;3. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;4. The Early Life Research Unit, Academic Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, University of Nottingham, Nottingham, NG7 2UH, Iran;5. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Human Nutrition, Medicine Faculty, Urmia University of Medical Sciences, Urmia, Iran;3. Food and Beverage Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran;1. Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran;3. Students'' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran;4. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Biochemistry and Diet Therapy, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;1. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel;2. Infectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel;3. Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, University, Hospital Centre Timone, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance Publique – Hôpitaux de Marseille, Marseille, France;4. Université Aix-Marseille, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM 63 CNRS 7278 IRD 198 INSERM U1095, Facultés de Médecine et de Pharmacie, Marseille, France;1. Department of Clinical Nutrition, School of Nutrition & Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Halal Research Center of IRI, FDA, Tehran, Iran;3. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;4. Physical Activity Research Group, Appleton Institute & School of Health Medical and Applied Sciences Central Queensland University, Brisbane, Australia;5. Division of Nutritional Sciences, Human Metabolic Research Unit, Cornell University, Ithaca, NY, USA;1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;2. Breast Disease Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran;3. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;4. Department of Microbiology, School of Biology Sciences, Islamic Azad University, Tehran, Iran;5. Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran;6. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;1. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Professor of Biostatistics. Isfahan Endocrine and Metabolism Research Center and Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | Background & aimsExisting evidence on the possible effects of pro-/synbiotics on overweight or obese children and adolescents has not been fully established. Therefore, the present review was undertaken to evaluate the overall effects of pro-/synbiotics supplementation on anthropometric indices and metabolic indices in overweight or obese children and adolescents.MethodsA systematic computerized literature search of PubMed, Scopus, ISI Web of science and Google Scholar databases was conducted up to November 2018. All RCTs using pro-/synbiotics supplements in overweight or obese children and adolescents included in this systematic review and meta-analysis.ResultsOverall 9 randomized trials including 410 subjects were identified for the present meta-analysis. Pooled analysis did not illustrate any significant changes in BMI z-score, waist circumference, weight, body fat, fasting blood sugar and lipid profiles (triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) after supplementation with pro-/synbiotics for 4–16 weeks. However, subgroup analysis by intervention type revealed a significant reduction of BMI z-score in synbiotic subgroups.ConclusionBased on our findings, modulation of gut microbiota composition through pro-/ synbiotic supplements did not have favorable effects to manage overweight or obese children and adolescents. Further large-scale studies are warranted to confirm present findings. |
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| Keywords: | Synbiotic Probiotic Obesity Children Meta-analysis |
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