Inhibitory Anti-Tumor Effects of Interleukin-4 on Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia and Other Hematopoietic Malignancies |
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Authors: | Mihiro Okabe Ikuo Saiki Tamotsu Miyazaki |
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Institution: |
a The third Department of Internal Medicine, School of Medicine, Sapporo, Japan
b The Section of Chemistry, Institute of Immunological Science, Hokkaido University, Sapporo, Japan |
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Abstract: | IL-4 has been shown to possess a broader spectrum of biological activities. Recently, anti-tumor activities of IL-4 on malignant tumors including hematopoietic tumors has been revealed in vitro or in vivo. We investigated the effect of recombinant human (rhIL-4) on the in vitro growth of human leukemia cells and demonstrated the inhibitory anti-tumor activity of rhIL-4 on Ph1-positive ALL cells in association with the decreased activity of cellular tyrosine kinase. This finding suggests that the clinical evaluation of rhIL-4 may offer promising therapeutic possibility for patients with Ph1-positive ALL. In this paper, we presented the IL-4-dependent inhibition of Ph1-positive ALL cells and reviewed implications for mechanism of IL-4-dependent inhibition and anti-tumor activities of IL-4. |
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Keywords: | Ph1 ALL interleukin-4 tyrosine kinase anti-tumor activity bcr/abl gene |
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