人胎视网膜血管发生方式的研究

目的：观察人胎视网膜血管的形成方式。方法：收集13～38周胎儿视网膜86例，免疫组织化学染色(ABC)法，光镜观察。结果：在胎儿12—13周时，间充质的梭形细胞从视盘处进入视网膜，并向锯齿缘迁移，同时分化、增殖为内皮细胞索，此索经管道化和改建成为节细胞层内的血管。第26周，节细胞层内已生成血管“出芽”，朝神经纤维层和内核层生长，分别在神经纤维层内和内核层的内、外缘各形成一层毛细血管网。结论：足月胎儿视网膜基本具有四层血管，分别由两种不同方式生成。 （中华眼底病杂志，1996，12：88-90）

A STUDY ON PROCESSES OF RETINAL VASCULAR DEVELOPMENT IN HUMAN FETUS

To investigate the processes of retinal vascular development of human fe-tus. METHODS:Eighty-six specimens of retinas of human fetus from 13th to 38th gestational week were studied by immunohistochemieal method(ABC). RESULTS:The spindle cells of mensenchymal origin was firstly found to migrate into the retina from optic disc at 12--13 weeks ,and spreaded subsequently toward the periphery of the retina. At the same time ,the consequential processes of differentiation,proliferation,canalilization and remodelling developed into vascular plexus in ganglion cell layer (GCL). Vascular buds formed in GCL in 26th gestational week extended toward nerve fiber layer (NFL)and inner nuclear layer(INL)and developed into capillary plexuses in NFL and inner and outer margin of INL respectively. CONCLUSIONS.. Four vascular layers could be distinguished in the ratina of full term fetuses,and these layers were formed through two principal developmental processes. （Chin J Ocul Fundus Dis,1996,12: 88- 90）