偏头痛患者脑干听觉诱发电位的变化及危险因素

目的探讨偏头痛(migraine)患者脑干听觉诱发电位(brainstem auditory evoked poten-tial,BAEP)的变化及危险因素。方法纳入52例偏头痛患者和50例健康对照者,均行BAEP检查。结果偏头痛患者BAEP异常率为71.15%,左侧Ⅴ波潜伏期(latency period,LP):偏头痛组为(5.65±0.29),对照组为(5.51±0.19),两组间差异有统计学意义(t=2.628,P=0.011);右侧Ⅲ波潜伏期:偏头痛组为(3.77±0.20),对照组为(3.68±0.16),两组间差异有统计学意义(t=2.050,P=0.044);右侧Ⅴ波潜伏期:偏头痛组为(5.67±0.23),对照组为(5.54±0.16),两组间差异有统计学意义(t=2.927,P=0.005);左侧Ⅲ～Ⅴ峰间期(interpeak latency,IPL):偏头痛组为(1.90±0.22),对照组为(1.78±0.21),两组间差异有统计学意义(t=2.354,P=0.021);右侧Ⅰ～Ⅲ峰间期:偏头痛组为(2.14±0.19),对照组为(2.03±0.12),两组间差异有统计学意义(t=2.502,P=0.014);右侧Ⅰ～Ⅴ峰间期:偏头痛组为(4.06±0.36),对照组为(3.89±0.16),两组间差异有统计学意义(t=2.206,P=0.030)。二分类logistic回归分析显示,性别[优势比(odds ratio,OR)=0.078,95%可信区间(confidence inter-val,CI)0.009-0.697;P=0.022],持续时间[优势比(odds ratio,OR)=1.121,95%可信区间(confi-dence interval,CI)0.991-1.191;P=0.041]与BAEP独立相关。结论偏头痛患者急性发作期脑干某些区域存在神经电生理改变,性别及头痛持续时间是其独立危险因素。

Changes and risk factors of BAEP in migraines

Objective To investigate the changes of brainstem auditory evoked potential(BAEP) and risk factors in migraines during attack.Methods 52 migraines and 50 controls were chosen.All were then examined by BAEP.Results 71.15% of migraines with abnormal BAEP.The significant prolongation of III and V wave latencies of BAEP was found in migraine patients only.Left V wave latency of migraines was 5.65±0.29 and control was 5.51±0.19(t=2.628,P=0.011);right III wave latency of migraines was 3.77±0.20 and control was 3.68±0.16(t=2.050,P=0.044);right V wave latency of migraines was 5.67±0.23 and control was 5.54±0.16(t=2.927,P=0.005).The significant prolongation of Ⅲ-Ⅴ,Ⅰ-Ⅲ and Ⅰ-Ⅴ interpeak latencies of BAEP was found in migraine patients only.Left Ⅲ-Ⅴ wave interpeak latency of migraines was 1.90±0.22 and control was 1.78±0.21(t=2.354,P=0.021);right Ⅰ-Ⅲ wave interpeak latency of migraines was 2.14±0.19 and control was 2.03±0.12(t=2.502,P=0.014);right Ⅰ-Ⅴ wave interpeak latency of migraines was 4.06±0.36 and control was 3.89±0.16(t=2.206,P=0.030).Binary logistic analysis showed that the gender(odds ratio = 0.078,95% confidence interval 0.009-0.697;P=0.022) and duration(odds ratio = 1.121,95% confidence interval 0.991-1.191;P=0.041) were independently correlated with BAEP.Conclusions Neurophysiological changes of certain areas of the brainstem were found in migrainers during attack,which were independently correlated with gender and duration.