细胞S相激酶相关蛋白表达与胃癌的临床关系

目的　探讨细胞S相激酶相关蛋白 (S -phasekinase -associatedprotein 2 ,SKP2 )表达与胃癌的临床关系。方法　用免疫组化S -P法检测 69例胃癌中SKP2、p2 7KIP1 蛋白的表达。结果　SKP2蛋白表达率在胃癌中为 33.33% ( 2 3/69) ,而正常胃组织中为 1 0 .71 % ( 3/2 8) ,差异有显著性 (P <0 .0 5 )。SKP2蛋白阳性表达率与患者年龄、性别、肿瘤大小、部位无关 (P >0 .0 5 ) ,与肿瘤分化程度有关 (P <0 .0 5 )。SKP2与p2 7KIP1 表达呈显著负相关 (P <0 .0 1 )。结论　SKP2异常表达可加速细胞周期转化 ,促进胃癌的发生 ,泛素 -蛋白酶体途径可能在胃癌发生中扮演着重要角色。

Clinical Relationship Between Expression of S-phase Kinase-associated Protein 2 and Gastric Cacinoma

Objective To investigate the clinical relationship between S-phase kinase-associated protein 2 (SKP2) expression and gastric carcinoma. Method Samples of 69 cases with gastric carcinoma were examined by immunohistochemical staining SP method for expressions of SKP2 and p27 KIP1 . Result Expression rate of SKP2 protein was 33.33%(23/69) in gastric carcinoma, while that was10.71%(3/28) in normal gastric tissue(P<0.05).The expression rate of SKP2 was not correlated with patient age, patient sex, tumor size, tumor position (P>0.05),but correlated with the differentiation (P<0.05). There was a significant inverse correlation between the expression of SKP2 and that of p27 KIP1 (P<0.01). Conclusions The abnormal expression of SKP2 may promote cell cycle progression and gastric carcinogenesis. Ubiquitin-proteasome pathway may play an important role in gastric carcinogenesis.