Survivin、p53、Ki-67在乳腺癌组织中的表达及其意义

目的 检测乳腺癌及癌旁组织中Survivin、p53、Ki-67蛋白的表达,探讨它们的相关性及临床意义。方法 采用免疫组化SP法检测60例乳腺癌组织,60例癌旁乳腺正常组织中Survivin、p53、Ki-67的表达。结果 60例乳腺癌组织中Survivin蛋白的阳性表达率为78.33%,明显高于癌旁正常组织5.00%（P〈0.05）,但与乳腺癌的病理分级和淋巴结转移状况无显著相关。p53和Ki-67在乳腺癌组织中表达高于癌旁组织,并与乳腺癌病理分级、腋窝淋巴结转移有关。乳腺癌组织中Survivin的表达与p53和Ki-67表达呈正相关。结论 Survivin、p53、Ki-67蛋白可通过抑制细胞凋亡,对乳腺癌发生和发展起重要作用,p53和Ki-67可以作为乳腺癌的预后指标。在乳腺癌发展中起协同作用。

The Expression and Significance of Survivin,p53 and Ki-67 in Breast Cancer

Objective To study the expression of Survivin,p53 and Ki-67 and to evaluate their correlations in breast cancer and paracacinoma normal tissues.Methods The expression of Survivin,p53 and Ki-67 in breast cancer (60cases) and paracacinoma normal tissues(60cases)were evaluated by SP immunohistochemistry.Results The positive rates of Survivin were 78.33% in breast cancer,5.00% in nomal tissues.The positive rate of Survivin expression was significantly higher in breast cancer than that in normal tissues.There were no correlations between the expression of Survivin and the histological grade or node metastasis.The expression of p53 and Ki-67 in breast cancer was also significantly higher than that in paracacinoma normal tissues.The expression of p53 and Ki-67 was correlated with the pathological grade and node metastasis.The expression of Survivin was positively correlated with p53 and Ki-67.Conclusion Survivin,p53 and Ki-67 may play an important role in the carcinogenesis and progress of breast cancer through the inhibition of apoptosis.They may play synergetic roles in the process of carcinogenesis of breast cancer.p53 and Ki-67 could be used as prognostic factors in breast cancer.