中药益智化学成分的研究

目的：研究中药益智Alpinia oxyphylla Miq.的化学成分。方法：利用各种色谱技术进行分离纯化,根据化合物的理化性质和光谱数据进行结构鉴定;用GC-MS联机技术鉴定挥发油的化学成分。结果：从益智分得10种化合物,其中2个二芳基庚酮:yakuchinone A (1)、益智醇(oxyphyllacinol 2),3个eremophilane烷碳架的倍半萜valencene (3)、nootkanone (4)、nootkanol (5),两个黄酮:杨芽黄酮(tectochrysin 6)、白杨素(chrysin 7),以及β-谷甾醇(8)、胡萝卜苷(9)和脂肪酸(10)。用GC-MS鉴定了挥发油中64个化学成分,其中含量较高的有:p-cymene (44.87%), valencene (9.13%), linalool (4.39%), myrtenal (3.90%), β-pinene (3.87%), α-pinene (2.93%), furopelargone (2.62%), terpinen-4-ol (2.56%)等。结论：益智醇(2)为新二芳基庚醇,其化学结构为1-(4′-hyroxy-3′-methoxy-phenyl)-7-phenyl-3-heptanol,3,6和7是首次从该植物分得。

STUDEIS ON THE CHEMICAL CONSTITUENTS OF THE FRUITS FROM ALPINIA OXYPHYLLA

AIM: To study the chemical constituents of the fruits of Alpinia oxyphylla Miq. METHODS: Various chromatographic techniques were used to separate and purify the constituents. Their physico-chemical properties and spectral data were measured for structure elucidation. GC-MS techniques were used to identify the chemical constituents of the volatile oil of A.oxyphylla. RESULTS: Ten compounds were isolated from the ethanol extract of A.oxyphylla. On the basis of spectral data (UV, IR, MS and NMR) and comparisons with known compounds, their structures were identified as two diarylheptanoids: yakuchinone A (1), oxyphyllacinol (2); three sesquiterpenes of eremophilane skeleton: valencene (3), nootkanone (4) and nootkanol (5); two flavones: tectochrysin (6) and chrysin (7); tow steroids: β-sitosterol (8) and daucosterol (9) and mixed fatty acids (10). Sixty four compounds were identified on the basis of GC-MS, the main compounds are: p-cymen (44.87%), valencene (9.13%), linalool (4.39%), myrtenal (3.90%), β-pinene (3.87%), α-pinene (2.93%), furopelargone A (2.62%) and terpinen-4-ol (2.56%). CONCLUSION: Compound 1 is a new diarylheptanol and its structure is 1-(4′-hyroxy-3′-methoxy-phenyl)-7-phenyl-3-heptanol. 3, 6 and 7 were isolated for the first time from this plant.