慢性阻塞性肺疾病急性加重期应用多索茶碱的临床效果分析

目的 探讨慢性阻塞性肺疾病急性加重期应用多索茶碱的疗效和安全性.方法 106例慢性阻塞性肺疾病急性加重期患者随机分为观察组和对照组.两组均给予抗感染、吸氧、祛痰、β2受体激动剂等常规内科治疗,观察组在此基础上给予多索茶碱治疗,对照组给予氨茶碱治疗,比较两组的治疗效果和不良反应发生情况.结果 观察组的总有效率高于对照组（P〈0.05）,肺功能及血气分析与对照组比较差异有统计学意义（P〈0.05）;观察组不良反应发生率低于对照组（P〈0.05）.结论 慢性阻塞性肺疾病患者急性加重期应用多索茶碱治疗效果较好,不良反应发生率较低,值得进一步在临床推广.

Effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease

Objective To explore the efficacy and safety of doxofylline in treating acute exacerbation of chronic obstructive pulmonary disease. Methods 106 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into observation group and control group. On the base of conventional medical treatment, such as anti-infection, oxygen therapy, sputum clearance, β2 receptor stimulant, observation group and the control group were treated with doxofylline and aminophylline respectively. The efficacy and adverse reaction of the two groups were observed. Results The observation group had better results in total effective rate, lung function, index of blood gas analysis （ P 〈 0. 05 ）. The incidence of side effects was more lower in observation group （ P 〈 0. 05 ）. Conclusion Doxofylline has good application value in acute exacerbation of chronic obstructive pulmonary disease with low incidence of adverse reactions, it deserves further clinical applications.