| PD-1／PD—Ls与免疫相关疾病的研究进展 |
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| 引用本文： | 崔斌,孙天胜.PD-1／PD—Ls与免疫相关疾病的研究进展[J].中国医药导报,2013(30):31-34. |
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| 作者姓名： | 崔斌 孙天胜 |
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| 作者单位： | [1]北京军区总医院骨科全军创伤骨科研究所,北京100700 [2]山西医科大学第二临床医学院,山西太原030001 |
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| 基金项目： | 国家国际科技合作计划（编号2010DFA31250）. |
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| 摘 要： | PD-1是CD28分子家族的成员之一，表达于多种免疫细胞表面，通过PD—L1或PD—L2表达负性调控信号。PD—l的免疫受体络氨酸转化基序（ITSM）磷酸化后可以募集SHP2降低PLCg2，P13K，VAV和ERKl／2的激活，进而调控免疫细胞的激活和免疫耐受。PD-1与其配体的相互作用在自身免疫性疾病，感染性疾病和肿瘤等方面均起重要作用。PD-1与其配体的生理学作用表明调控PD-1途径是治疗人类多种疾病的一个靶向目标。本文总结了PD-1与其配体的免疫调控功能以及在相关性疾病中的临床意义。
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| 关 键 词： | PD-1 PD—Ls 免疫功能 |
PD-1/PD-Ls on the immune-related diseases of research progress |
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| Institution: | CUI Bin, SUN Tianshen(1.Institute of Orthopaedics and Trauma, Beijing Military General Hospital of PEA, Beijing 100700, China; 2.The Second Clinical Medical College of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China) |
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| Abstract: | PD-1 is a member of the CD28 family of molecules expressed on the surface of a variety of immune cells, through the PD-L1 or PD-L2 expression of negative regulatory signals. The phosphorylated immune receptor tyrosine conversion motif （ITSM） of PD-1 can raise SHP2 which could attenuate the activation of PLCg2, PI3K, VAV and ERK1/2, and then PD-1 reg-ulates the activation of immune cell and immune tolerance. PD-1 and its ligands interactions play crucial roles in autoimmune diseases, infectious diseases and tumors. The biological role of PD-1 and its ligands suggest that manipulated PD-1 pathway may be a target for treating many human diseases. In this review, we summarize the PD-1 and its ligands ranging from the immune regulation function to the related diseases of clinical significance. |
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| Keywords: | Programmed death-l Programmed death ligands Immune function |
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