坦索罗辛治疗体外震波碎石后石街的临床观察

目的探讨坦索罗辛治疗体外震波碎石术后石街的临床疗效。方法选择60例石街位于输尿管下段患者,随机分为两组。对照组30例给予非甾体消炎止痛药西乐葆200mg,1次/d。实验组30例使用坦索罗辛0.4mg,1次/d,加保守治疗,疗程4周,观察所有患者排石过程中输尿管绞痛发生的频率程度以及排石率。并按照VAS评分进行临床效果评价。结果结石的排出率分别为:对照组63.3%(19/30),实验组76.6%(23/30),两组比较结果无显著性差异(P>0.05)。对照组输尿管绞痛的发生频率和程度明显高于实验组(P<0.01)。实验组VAS评分则明显低于对照组(P<0.001)。结论坦索罗辛有益于减少石街患者排石过程中绞痛的发生频率和程度。

Clinical Study of Tamsulosin in Treatment of Patients with Steinstrasse Developing after Extracorporeal Shock Wave Lithotripsy

Objective To evaluate whether tamsulosin, as an alpha 1-blocker, was effective for the treatmeat steinstrasse in the lower ureter after shock wave lithotripsy. Methods Toelect of 60 patients (48 men and 12 women) with steinstrasse in the lower portion of ureters were randomly, conservative treatment, 30 patients in the control group was given celexB (200 mg orally once daily), as a non-steroidal anti-inflammatory drug, 30 patients in the trial group was given Tamsulosin (0.4 mg daily) in addition to the conservative treatment, all patients were reevaluated and question about the number of episodes and severity of ureteral colic and the rate of spontaneous resolution of steinstrasse 4 weeks after beginning treatment they were asked to score the severity of pain according to a visual analog scale. Results In 19(63.3%) of 30 patients in the control group, and in 23(76.6%) of 30 patients in the trial group, steinstrasse resolve during the 4 weeks the resolution rates were not significantly different (P > 0.05). Among both groups, the control group had more ureteral colic episodes than did the trial group while passing their stone, this difference was statistically significant (P < 0.01). In the trial group patients VAS were lower significantly than that of control group (P < 0.001). Conclusion The addition of tamsulosin to conservative treatment seemed to be beneficial in terms of the reduced number of ureteral colic episodes and the severity of pain, and improved the quality of life in the patients who developed steinstrasse after shock wave L:thotripsy.