| 人参皂甙单体Rb_1对豚鼠心肌细胞ICa~(2+)电流阻滞作用的研究 |
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| 引用本文： | 曾庆华,战术,张文杰,孙晓霞,钟国赣.人参皂甙单体Rb_1对豚鼠心肌细胞ICa~(2+)电流阻滞作用的研究[J].吉林大学学报(医学版),1997(3). |
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| 作者姓名： | 曾庆华 战术 张文杰 孙晓霞 钟国赣 |
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| 作者单位： | 基础医学院生理教研室 |
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| 摘 要： | 研究人参单体Ｒｂ１对ＩＣａ２＋电流的影响。采用全细胞电压钳技术记录了豚鼠心室肌细胞ＩＣａ２＋电流，绘出了电流—电压关系曲线。在保持电压－５０ｍＶ时，阶跃命令在一５０～＋６０ｍＶ，０ｍＶ时电流最大。并发现Ｒｂ１对ＩＣａ２＋电流有明显的阻滞作用。而且在１００μｍｏｌ／Ｌ，２００μｍｏｌ／Ｌ，３００μｍｏｌ／Ｌ，４００μｍｏｌ／Ｌ范围时有剂量依赖关系。
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| 关 键 词： | 人参单位体Rb1全细胞电压钳钙电流豚鼠心室肌细胞 |
Study of ginsenoside monomer Rb 1 on whole cell ICa 2+ blockade action in ventricular myocytes of guinea pig |
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| Zeng Qinghua,Zhan Shu,Zhang Wenjie,et al.Study of ginsenoside monomer Rb 1 on whole cell ICa 2+ blockade action in ventricular myocytes of guinea pig[J].Journal of Jilin University: Med Ed,1997(3). |
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| Authors: | Zeng Qinghua Zhan Shu Zhang Wenjie |
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| Institution: | Dept.of physiology The School of Basic Medical Sciences |
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| Abstract: | In order to research the effect of Rb 1 on ICa 2+ ,we studied the ginsenoside monomer Rb 1 on whole cell ICa 2+ blockade in ventricular myocytes of guinea pig using patch clamp.ICa 2+ was recorded in ventricular myocytes and a curve of current-voltage relationships of Ica 2+ was drawn.At hold-50 mV ,command -50 mV to +60 mV ,the peak current of ICa 2+ was o mV of command.The result indicated that Rb 1 being in from 100 μmol/L to 400 μmol/L. |
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| Keywords: | Ginsenoside monomer Rb 1 Whole cell patch clamp Calcium current Ventricular myocytes |
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