严重冠心病患者血清碱性成纤维细胞生长因子与冠状动脉侧支循环的相关性

目的探讨冠状动脉严重狭窄患者血清碱性成纤维细胞生长因子浓度与冠状动脉侧支循环形成、冠状动脉粥样硬化程度的关系。方法根据冠状动脉造影结果连续入选80例冠状动脉严重狭窄患者,按照Rentrop分级方法对冠状动脉侧支循环进行分级:0级26例,1级22例,2级18例,3级14例,采用酶联免疫吸附法检测血清碱性成纤维细胞生长因子浓度,并应用Gensini积分系统评价冠状动脉粥样硬化病变程度。结果冠状动脉侧支循环0级组碱性成纤维细胞生长因子血清水平为20.75±6.89 ng/L,1级组为22.04±5.18 ng/L,2级组为27.32±6.14ng/L,3级组为32.27±12.04 ng/L,随着侧支循环分级的增加,碱性成纤维细胞生长因子血清水平也相应增高(P<0.05);Spearman相关分析发现,冠状动脉侧支循环分级与碱性成纤维细胞生长因子血清水平呈正相关(P<0.01)。结论在冠状动脉严重狭窄的冠心病患者中,冠状动脉侧支循环形成良好患者碱性成纤维细胞生长因子血清浓度高于冠状动脉侧支循环形成不良患者;碱性成纤维细胞生长因子血清浓度与冠状动脉侧支循环分级呈正相关。

The Relationship Between Basic Fibroblast Growth Factor and Coronary Collateral Circulation In Patients with Severe Coronary Artery Disease

Aim To investigate the relationship between serum concentration of basic fibroblast growth factor(bFGF) and coronary collateral circulation(CCC) and the severity of atherosclerosis. Methods 80 patients with severe coronary stenosis were recruited.The CCC were rated by Rentrop rating system: rate 0(n=26),rate 1(n=22),rate 2(n=18),rate 3(n=14).Serum concentrations of bFGF were measured by ELISA,and the severity of coronary artery atherosclerosis was evaluated by Gensini''s score system. Results The serum concentrations of bFGF were 20.75±6.89 ng/L,22.04±5.18 ng/L,27.32±6.14 ng/L and 32.27±12.04 ng/L in patients with CCC rate 0,1,2 and 3 group respectively.The serum concentrations of bFGF was increased with CCC rating(p<0.05).Spearman corelation analysis demonstrated that there was a positive correlation between CCC rating and the serum bFGF concentrations(p<0.01). Conclusions In patients with severe coronary artery disease,serum concertrations of bFGF in groups with better CCC formation were significantly higher than those in groups with bad CCC formation.Serum bFGF concentrations showed a positive correlation with the rating of coronary collateral circulation formation.