细胞免疫与烧伤创面愈合的实验研究

为探讨免疫低下对烧伤创面愈合的影响，设计了用低剂量钴源照射的方法建立的免疫抑制模型，并在该模型的基础上观察了免疫抑制大鼠Ⅱ度烧伤创面愈合的情况。结果表明：①大鼠接受２Ｇｙ６０Ｃｏ照射后２０天内，Ｔｈ／Ｔｓ比值和Ｔ细胞肿瘤花环率持续下降。照射后皮肤组织ＤＮＡ含量及细胞周期均无明显改变。②免疫抑制大鼠胶原修复能力下降，创面愈合百分率低于正常大鼠。由此证实了免疫功能低下对创面愈合的抑制作用。

Experimental study on immunity and burn wound healing

The immune system is involved in the complicated process of wound healing. In this study, we at first set up an optimal immuno suppression model with low doze radiation with 60 Co and found that both the ratio of Th/Ts in peripheral blood and the rate of T cells adhesion to tumour cells dropped persistently, and there were no significant injuries to skin tissue DNA and cells cycle in 20 days after 2Gy radiation with 60 Co. Then we investigated the influence of immuno suppression on burn wound healing. The results showed that both ability of collagen repair and rates of wound healing after burn injury were inhibited in immuno suppression rats. This indicated that it was necessary to improve immunity condition to enhance wound healing after severe burn injury.